Apo A1 / Apo B Ratio and Acute Coronary Syndrome Among Peritoneal Dialysis Patients

Abstract

Background: Acute coronary syndrome (ACS) is prevalent in continuous ambulatory peritoneal dialysis (CAPD) patients. But the association between apoprotein profile and ACS is not well known. Therefore, we aimed to investigate the relationship between apoproteins and ACS in CAPD patients.Methods: Eighty-one CAPD patients were included in this retrospective study. The primary endpoint was ACS. Predictors were baseline apoprotein levels, particularly the ratio of apoprotein A1 (Apo A1) / apoprotein B (Apo B). Binary logistics regression was used to determine the relationship between Apo A1 / Apo B and ACS. Results: During follow-up, 34 (41.98%) CAPD patients experienced an ACS. ACS patients had higher levels of total cholesterol (p = 0.03), LDL-C (p = 0.04), CRP (p = 0.01), and Apo B (p < 0.01). However, hemoglobin (p = 0.01) and the Apo A1 / Apo B (p < 0.01) were lower in the ACS group than the non-ACS group. Patients with Apo A1 / Apo B ≥ 1.105 experienced fewer ACS compared with those with Apo A1 / Apo B < 1.105 (33.33% vs. 75.56%, p = 0.03). In binary logistics regression, Apo A1 / Apo B (OR, 0.01; 95% CI, 0.00-0.77; p = 0.04) was independently associated with ACS. Conclusions: Apo A1 / Apo B were strongly associated with ACS, and may be considered as a predictor of future ACS in CAPD patients.