ApoE ɛ4 is not associated with posictal confusion in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

Kauffman, Marcelo; Silva, Nahuel Pereira de; Consalvo, D.; Kochen, Silvia

doi:10.1016/j.eplepsyres.2009.03.012

Cited by 7 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 14 However, there are other studies that failed to find a significant association between TLE and APOE polymorphisms in several populations including Han Chinese people. 18 , 28 …”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E ε4 Allele was Associated With Nonlesional Mesial Temporal Lobe Epilepsy in Han Chinese Population

Ding

Gong

et al. 2016

Medicine

View full text Add to dashboard Cite

Apolipoprotein E (APOE) gene has been implicated as one of the genes susceptible to temporal lobe epilepsy (TLE), but the association is inconsistent. We carried out a study to investigate the association of APOEε4 allele with a subtype of TLE-nonlesional mesial temporal lobe epilepsy (NLMTLE) in Han Chinese people.The study consisted of total 308 NLMTLE patients and 302 controls in Han Chinese. The APOE polymorphisms were genotyped using polymerase chain reaction (PCR) DNA sequencing. We compared the frequency of APOEε4 allele and carrying status between NLMTLE patients and control subjects to test for the association of APOEε4 allele with NLMTLE clinical status.Carrying status of APOEε4 allele was significantly associated with the risk of NLMTLE. No effect of APOEε4 allele was found on the age of onset, duration of epilepsy, or frequency of seizure. Moreover, there was no association between APOEε4 allele and hippocampal sclerosis (HS) or febrile convulsion (FC) history.Our study provided an evidence that APOEε4 allele was a possible risk factor for NLMTLE, and further study with a larger sample is needed to warrant this finding.

show abstract

“… 14 However, there are other studies that failed to find a significant association between TLE and APOE polymorphisms in several populations including Han Chinese people. 18 , 28 …”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E ε4 Allele was Associated With Nonlesional Mesial Temporal Lobe Epilepsy in Han Chinese Population

Ding

Gong

et al. 2016

Medicine

View full text Add to dashboard Cite

show abstract

“…Another study reported that ApoEε4 allele in intractable TLE affect both verbal and non-verbal memory performance [ 218 ] and increases the risk of post-ictal confusion [ 219 ]. While Kauffman et al did not find any association with the same [ 220 ]. A study in the Han Chinese population suggest that ApoEε4 allele is involved in development of TLE in patients with prior brain trauma [ 221 ] and is a risk factor for non-lesional MTLE [ 222 ].…”

Section: Genetic Studies Of Common Epilepsiesmentioning

confidence: 99%

Genetic Landscape of Common Epilepsies: Advancing towards Precision in Treatment

Thakran

Guin

Singh

et al. 2020

IJMS

View full text Add to dashboard Cite

Epilepsy, a neurological disease characterized by recurrent seizures, is highly heterogeneous in nature. Based on the prevalence, epilepsy is classified into two types: common and rare epilepsies. Common epilepsies affecting nearly 95% people with epilepsy, comprise generalized epilepsy which encompass idiopathic generalized epilepsy like childhood absence epilepsy, juvenile myoclonic epilepsy, juvenile absence epilepsy and epilepsy with generalized tonic-clonic seizure on awakening and focal epilepsy like temporal lobe epilepsy and cryptogenic focal epilepsy. In 70% of the epilepsy cases, genetic factors are responsible either as single genetic variant in rare epilepsies or multiple genetic variants acting along with different environmental factors as in common epilepsies. Genetic testing and precision treatment have been developed for a few rare epilepsies and is lacking for common epilepsies due to their complex nature of inheritance. Precision medicine for common epilepsies require a panoramic approach that incorporates polygenic background and other non-genetic factors like microbiome, diet, age at disease onset, optimal time for treatment and other lifestyle factors which influence seizure threshold. This review aims to comprehensively present a state-of-art review of all the genes and their genetic variants that are associated with all common epilepsy subtypes. It also encompasses the basis of these genes in the epileptogenesis. Here, we discussed the current status of the common epilepsy genetics and address the clinical application so far on evidence-based markers in prognosis, diagnosis, and treatment management. In addition, we assessed the diagnostic predictability of a few genetic markers used for disease risk prediction in individuals. A combination of deeper endo-phenotyping including pharmaco-response data, electro-clinical imaging, and other clinical measurements along with genetics may be used to diagnose common epilepsies and this marks a step ahead in precision medicine in common epilepsies management.

show abstract

“…Results were inconsistent. Chapin and colleagues found an association (68% of ε 4 + and 43% of ε 4 − , P = 0.04) [92], whereas Kauffman and coworkers did not (30.4% of ε 4 + and 46.3% of ε 4 − , P = 0.2) [93]. A final study investigated if ApoEε 4 allele is associated with increased risk of late onset posttraumatic seizures, early onset, refractory complex partial seizures (CPSs), and postictal confusion in a Chinese population with TLE.…”

Section: Sporadic Tle Casesmentioning

confidence: 99%

Genetics of Temporal Lobe Epilepsy: A Review

Salzmann

Malafosse

2012

Epilepsy Research and Treatment

View full text Add to dashboard Cite

Temporal lobe epilepsy (TLE) is usually regarded as a polygenic and complex disorder. To understand its genetic component, numerous linkage analyses of familial forms and association studies of cases versus controls have been conducted since the middle of the nineties. The present paper lists genetic findings for TLE from the initial segregation analysis to the most recent results published in May 2011. To date, no genes have been clearly related to TLE despite many efforts to do so. However, it is vital to continue replication studies and collaborative attempts to find significant results and thus determine which gene variant combination plays a definitive role in the aetiology of TLE.

show abstract

ApoE ɛ4 is not associated with posictal confusion in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

Cited by 7 publications

References 15 publications

Apolipoprotein E ε4 Allele was Associated With Nonlesional Mesial Temporal Lobe Epilepsy in Han Chinese Population

Apolipoprotein E ε4 Allele was Associated With Nonlesional Mesial Temporal Lobe Epilepsy in Han Chinese Population

Genetic Landscape of Common Epilepsies: Advancing towards Precision in Treatment

Genetics of Temporal Lobe Epilepsy: A Review

Contact Info

Product

Resources

About