APOE ε4 is associated with impaired verbal learning in patients with MS

Πάνας, Μάριος; Giogkaraki, Erasmia; Potagas, Constantinos; Karadima, Georgia; Sfagos, Constantinos; Vassilopoulos, Dimitris

doi:10.1212/01.wnl.0000254468.51973.44

Cited by 38 publications

(19 citation statements)

References 27 publications

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“…Regional decreases in choline acetyltransferase in the hippocampus might explain these deficits [126]. This is in accordance with MS studies on human [114, 127]. …”

Section: The Role Of Apoe In Eaesupporting

confidence: 79%

“…Cognitive impairment is now considered one of the earliest manifestations of the disease, which can affect up to 65% of MS cases [110, 111]. The association between APOE ε 4 allele and cognitive deficits in MS has been verified by dozens of studies [112–114]. However, there usually lacks robust interpretation of the cognitive impairment in MS in most studies, which can either be only a symptom on account of myelin damage and axonal loss, suggesting the severity of the disease, or be at a subclinical stage of neurodegenerative diseases such as Alzheimer's disease, irrelevant of the disease of MS per se.…”

Section: The Role Of Apoe In Msmentioning

confidence: 99%

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The Immune‐Modulatory Role of Apolipoprotein E with Emphasis on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Zhang

Zhu

2010

Journal of Immunology Research

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Apolipoprotein E (apoE) is a 34.2 kDa glycoprotein characterized by its wide tissue distribution and multiple functions. The nonlipid-related properties of apoE include modulating inflammation and oxidation, suppressing T cell proliferation, regulating macrophage functions, and facilitating lipid antigen presentation by CD1 molecules to natural killer T (NKT) cells, and so forth. Increasing studies have revealed that APOE ε allele might be associated with multiple sclerosis (MS), although evidence is still not sufficient enough. In this review, we summarized the current progress of the immunomodulatory functions of apoE, with special focus on the association of APOE ε allele with the clinical features of MS and of its animal model experimental autoimmune encephalomyelitis (EAE).

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“…Regional decreases in choline acetyltransferase in the hippocampus might explain these deficits [126]. This is in accordance with MS studies on human [114, 127]. …”

Section: The Role Of Apoe In Eaesupporting

confidence: 79%

Section: The Role Of Apoe In Msmentioning

confidence: 99%

The Immune‐Modulatory Role of Apolipoprotein E with Emphasis on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Zhang

Zhu

2010

Journal of Immunology Research

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“…Seven studies [19,21,[43][44][45][46][47] were excluded due to the number of alleles that couldn't be extracted. Thus, 20 studies which met the inclusion consisted of 5472 patients/4727 controls for ε4 allele and 4636 patients/4047 controls for ε2 allele were considered in meta-analysis.…”

Section: Studies Included In Meta-analysismentioning

confidence: 99%

No association between APOE epsilon 4 allele and multiple sclerosis susceptibility: A meta-analysis from 5472 cases and 4727 controls

Xuan

Zhang

et al. 2011

Journal of the Neurological Sciences

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“…Finally, we assessed the influence of genetic markers and cognitive decline in patients with MS, such as the ApoE4 genotype because it is associated with the presence of cognitive impairment in MS [22]. In our cohort, eight patients were ApoE4 positive (including two homozygous individuals) and 28 were ApoE4 negative.…”

Section: Changes In the Prevalence Of Cognitive Impairment After Two mentioning

confidence: 99%

Memory decline evolves independently of disease activity in MS

et al. 2008

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Background The natural history of cognitive impairment in multiple sclerosis (MS) and its relationship with disease activity is not well known. In this study, we evaluate a prospective cohort of 44 MS patients who were followed every 3 months for 2 years. Cognitive evaluation was done at baseline and by the end of the study using the Brief Repeatable Battery-Neuropsychology. Clinical evaluation included assessment of new relapses and changes in disability (Extended Disability Status Scale (EDSS)) confirmed at 6 months. Results We found that verbal memory performance deteriorates after 2 years in patients with MS. These changes were observed in stable and active patients both in terms of relapses and disability progression, even at the beginning of the disease, and in patients with or without cognitive impairment at study entry. Attention and executive functions measured with the symbol digit modality test (SDMT) declined after 2 years in patients with confirmed disability progression. Furthermore, SDMT performance correlated with the EDSS change. Conclusions Our findings indicate that verbal memory steadily declines in patients with MS from the beginning of the disease and independently of other parameters of disease activity. Multiple Sclerosis 2008; 14: 947-953.

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APOE ε4 is associated with impaired verbal learning in patients with MS

Abstract: We found an association of APOE epsilon4 with impaired verbal learning in patients with multiple sclerosis.

Cited by 38 publications

References 27 publications

The Immune‐Modulatory Role of Apolipoprotein E with Emphasis on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

The Immune‐Modulatory Role of Apolipoprotein E with Emphasis on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

No association between APOE epsilon 4 allele and multiple sclerosis susceptibility: A meta-analysis from 5472 cases and 4727 controls

Memory decline evolves independently of disease activity in MS

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