Apolipoprotein A-IV: a protein intimately involved in metabolism

Wang, Fei; Kohan, Alison B.; Lo, CM; Liu, Min; Howles, Philip N.; Tso, Patrick

doi:10.1194/jlr.r052753

Cited by 132 publications

(111 citation statements)

References 150 publications

(187 reference statements)

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“…Apo A-IV is found in plasma on chylomicrons and HDL, but 40-50% circulates lipid free. 30 Its levels could be modified in other pathologies not analyzed in this study, such as coronary artery disease and renal impairment. 31,32 SREBP-1c is a transcription factor involved in the regulation of lipogenesis.…”

Section: (Fas) (F) Apolipoprotein A-iv (Apo A-iv) (G) Diacylglyceromentioning

confidence: 89%

The expression of genes involved in jejunal lipogenesis and lipoprotein synthesis is altered in morbidly obese subjects with insulin resistance

Gutiérrez-Repiso

Rodríguez‐Pacheco

García-Arnés

et al. 2015

Laboratory Investigation

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Section: (Fas) (F) Apolipoprotein A-iv (Apo A-iv) (G) Diacylglyceromentioning

confidence: 89%

The expression of genes involved in jejunal lipogenesis and lipoprotein synthesis is altered in morbidly obese subjects with insulin resistance

Gutiérrez-Repiso

Rodríguez‐Pacheco

García-Arnés

et al. 2015

Laboratory Investigation

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“…In addition to modulating food intake, Apo A-IV has beneficial glycemic effects and has been shown to act as an incretin but with a substantially longer half-life than GLP-1 or GIP 96 . Thus, Apo A-IV represents a potential therapeutic target either alone or in combination.…”

Section: Apolipoprotein A-iv (Apo A-iv)mentioning

confidence: 99%

The Importance of the Gastrointestinal Tract in Controlling Food Intake and Regulating Energy Balance

Monteiro

Batterham

2017

Gastroenterology

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The gastrointestinal (GI) tract, the key interface between ingested nutrients and the body, plays a critical role in regulating energy homeostasis. Gut-derived signals convey information regarding incoming nutrients to the brain, initiating changes in eating behavior and energy expenditure, to maintain energy balance. Here we review hormonal, neural and nutrient signals emanating from the GI tract and evidence for their role in controlling feeding behavior. Mechanistic studies that have utilized pharmacological and/or transgenic approaches targeting an individual hormone/mediator have yielded somewhat disappointing bodyweight changes, often leading to the hormone/mediator in question being dismissed as a potential obesity therapy. However, the recent finding of sustained weight-reduction in response to systemic administration of a long-acting analog of the gut-hormone glucagon-like peptide-1 (GLP-1) highlights the therapeutic potential of gut-derived signals acting via non-physiological mechanisms. Thus, we also review therapeutics strategies being utilized or developed to leverage GI signals in order to treat obesity.

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“…As summarised by Wang et al [37], ApoA-IV has potent antioxidant and anti-inflammatory properties, and has been suggested to reduce food intake by increasing satiety (at least in animal models). These properties all have the potential to prevent type 2 diabetes development [3,38,39].…”

Section: Discussionmentioning

confidence: 99%

MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study

et al. 2016

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Aims/hypothesis Individuals at a high risk of type 2 diabetes demonstrate moderate impairments in glucose metabolism years before the clinical manifestation of type 2 diabetes, a state called 'prediabetes'. In order to elucidate the pathophysiological processes leading to type 2 diabetes, we aimed to identify protein biomarkers associated with prediabetes. Methods In a proteomics study, we used targeted selected reaction monitoring (SRM)-MS to quantify 23 candidate proteins in the plasma of 439 randomly selected men and women aged 47-76 years from the population-based German KORA F4 study. Cross-sectional associations of protein levels with prediabetes (impaired fasting glucose and/or impaired glucose tolerance), type 2 diabetes, glucose levels in both the fasting state and 2 h after an OGTT, fasting insulin and insulin resistance were investigated using regression models adjusted for technical covariables, age, sex, BMI, smoking, alcohol intake, physical inactivity, actual hypertension, triacylglycerol levels, total cholesterol/HDL-cholesterol ratio, and high-sensitivity C-reactive protein levels.

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Apolipoprotein A-IV: a protein intimately involved in metabolism

Cited by 132 publications

References 150 publications

The expression of genes involved in jejunal lipogenesis and lipoprotein synthesis is altered in morbidly obese subjects with insulin resistance

The expression of genes involved in jejunal lipogenesis and lipoprotein synthesis is altered in morbidly obese subjects with insulin resistance

The Importance of the Gastrointestinal Tract in Controlling Food Intake and Regulating Energy Balance

MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study

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