Apolipoprotein A1 Gene Polymorphism (G-75a and C+83t) in Myocardial Infarction—a Pilot Study in the North Indian Population

Dawar, Rajni; Gurtoo, Anil; Singh, Ranju

doi:10.1016/j.atherosclerosis.2009.09.063

Cited by 9 publications

(10 citation statements)

References 5 publications

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“…Of course, in our study, the concentration of lipids in the GG genotype was slightly higher than that for the other genotypes, but no significant difference was observed. The results of our study in this regard were not consistent with the results of other studies (19,30,36,(38)(39)(40).…”

Section: Discussioncontrasting

confidence: 56%

“…ApoAI gene is a part of the apolipoprotein apoAI/CIII/AIV gene cluster located on chromosome 11q23 (16). The apoAI gene SNPs were evaluated under different conditions, such as obesity (17,18), myocardial infarction (19)(20)(21)(22), diabetes, and metabolic syndrome (23,24). (G-75A) and (C83T), the most important polymorphic sites in the apoAI gene, are located in the upstream regulatory region and the first intron of apoAI gene, respectively (14).…”

Section: Introductionmentioning

confidence: 99%

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Association Between MspI Polymorphisms of the Apolipoprotein A-I Gene and Hyperlipidemia in an Iranian Population

Pakdel

Eidgahi

Bandegi

2018

Middle East J Rehabil Health Stud

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Background: One of the most important metabolic disorders is hyperlipidemia. ApoAI protein plays an important role in lipoprotein metabolism. In this study, the association between MspI polymorphisms in the promoter (G-75A) and first intron (C83T) of the apoAI gene and hyperlipidemia was investigated in Semnan, Iran. Methods: A total of 151 unrelated subjects were divided into two groups: the hyperlipidemic (N = 75) and control (N = 76) groups. Genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: In the hyperlipidemic group, the frequency of the (+-) variant of the MspI (C83T) locus was higher than that in the control group (P < 0.05). Significant differences were found in serum HDL-C and apoAI levels between different genotypes of MspI (C83T) (P < 0.001 and P = 0.02, respectively). In the hyperlipidemic group, the odds ratios for the (+-) and (-) genotypes of the MspI (C83T) locus in comparison to that for the (++) genotype were 0.26 (P= 0.023) and 3.62 (P = 0.254), respectively. The allelic frequency at the (G-75A) locus was not significantly different in the hyperlipidemic and control groups (P = 0.36). The serum levels of lipid and lipoprotein were not significantly different for all genotypes of MspI (G-75A). The AA/++ and GG/-haplotypes had the lowest and

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Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Association Between MspI Polymorphisms of the Apolipoprotein A-I Gene and Hyperlipidemia in an Iranian Population

Pakdel

Eidgahi

Bandegi

2018

Middle East J Rehabil Health Stud

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“…The potential association between the GALNT2 polymorphisms and plasma or serum lipid levels in humans has been proved by several previous GWAs studies. These researches have confirmed that the minor allele of GALNT2 polymorphisms was related to low HDL-C and high TG blood levels [11][12][13][14].…”

Section: Discussionsupporting

confidence: 53%

“…Apolipoprotein E (ApoE), along with ApoA, ApoB, ApoC, ApoD, ApoM, ApoH, ApoJ, and ApoL are members of the apolipoprotein gene family [13]. The APOE gene is composed of 4 exons and 3 introns, spans 3597 nucleotides, and encodes a 299-amino acid polypeptide.…”

Section: Introductionmentioning

confidence: 99%

Gene environment interaction of GALNT2 and APOE gene with hypertension in the Chinese Han Population

Zhang

Zhao

Jietao

et al. 2015

BME

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Abstract.In some GWAs studies, GALNT2 and APOE polymorphisms have been identified to be related to alterations of plasma or serum HDL-C and TG concentrations. The purpose of our study is to assess the contribution of GALNT2 rs4846914, APOE rs429358, rs7412, rs405509 variants, and several environmental factors to the development of hypertension disease in the China Han population. A hospital-based case-control study was conducted. Cases were hypertension (n=211) and controls were normal participants (n=434). The AA, AG, and GG genotype frequencies of GALNT2 rs4846914 were 22.8%, 43.1%, and 34.1% in hypertension subjects, and 35.3%, 44.2%, and 20.5% in controls (P<0.05), respectively. The OR of the AG genotype adjusted for all risk factors compared to the AA genotype was 1.61 (95%CI: 1.02 to 2.56) and to the GG genotype 2.67 (95%CI: 1.59 to 4.488). There was no significant difference between the APOE rs429358, rs7412, and rs405509 genotype frequencies in hypertension and control subjects. The present work indicates that SNP rs4846914 in GALNT2 gene is related to an increased risk of hypertension in China Han population, but the APOE gene is not.

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“…Apolipoprotein E (ApoE), along with ApoA, ApoB, ApoC, ApoD, ApoM, ApoH, ApoJ, and ApoL, are members of the apolipoprotein gene family (Dawar et al, 2010). The apoE gene consists of 4 exons and 3 introns, spanning 3597 nucleotides, and encoding a 299-amino acid polypeptide.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of +2836 G>A in the apoE gene are strongly associated with the susceptibility to essential hypertension in the Chinese Hui population

Yang¹,

Xu²,

Liu³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. In the present study, the correlation of polymorphisms of the apolipoprotein E (apoE) gene with the susceptibility of essential hypertension (EH) was investigated. Single nucleotide polymorphisms of the apoE gene at the -491 A>T, +969 C>G, and +2836 G>A sites were determined in 221 non-EH individuals and 109 subjects with EH of Chinese Hui ethnicity using polymerase chain reaction-restriction fragment length polymorphism analysis. The results showed that neither the genotypic frequency nor the allelic frequency at the -491 A>T and +969 C>G sites exhibited a statistically significant difference between these two groups (P > 0.05). However, a significant difference was observed in genotypic frequency and allelic frequency at the +2836 G>A site between EH patients and non-EH individuals (P < 0.01). In addition, a significantly higher frequency of the A allele at the +2836 G>A site was also detected in EH patients (83%) compared with controls (47.5%) (P < 0.01; OR = 4.82, 95%CI = 3.25-7.17); Polymorphisms of the apoE gene in the Chinese Hui population in contrast, the frequency of the G allele at the +2836 G>A site was significantly lower (17%) in the patient group in comparison with the non-EH cohorts (52.5%) (P < 0.01; OR = 0.21, 95%CI = 0.14 -0.31). These results suggest that the polymorphism at the +2836 G>A site in the apoE gene is strongly correlated with the susceptibility to EH in the Chinese Hui ethnic population.

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Apolipoprotein A1 Gene Polymorphism (G-75a and C+83t) in Myocardial Infarction—a Pilot Study in the North Indian Population

Cited by 9 publications

References 5 publications

Association Between MspI Polymorphisms of the Apolipoprotein A-I Gene and Hyperlipidemia in an Iranian Population

Association Between MspI Polymorphisms of the Apolipoprotein A-I Gene and Hyperlipidemia in an Iranian Population

Gene environment interaction of GALNT2 and APOE gene with hypertension in the Chinese Han Population

Polymorphisms of +2836 G>A in the apoE gene are strongly associated with the susceptibility to essential hypertension in the Chinese Hui population

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