Apolipoprotein B gene polymorphisms are associated with lipid levels in men of South Asian descent

Hh, Renges; Db, Wile; Pm, McKeigue; Marmot, Michael; Humphries, Steve E.

doi:10.1016/0021-9150(91)90174-2

Cited by 66 publications

(43 citation statements)

References 33 publications

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“…Our results in this population of obese subjects on spontaneous diet show an increase of the concentration of the LDL-cholesterol with the Del allele, which is in good agreement with most of the studies [7][8][9][10][11][12][13][14][15] but not all. [21][22][23] Nevertheless, the discrepancies between studies could be due to a different selection of subjects, in particular concerning the BMI, since in the latter studies, [21][22][23] subjects are described as 'healthy' or 'normal'.…”

Section: Discussionsupporting

confidence: 92%

“…6 In epidemiological studies, the Del allele has been associated with altered lipid levels, mainly increased plasma total and LDL-cholesterol concentrations. [7][8][9][10][11][12][13][14] A recent meta-analysis has shown that subjects with the Del/Del apoB genotype had higher cholesterol levels and an increased risk of coronary heart disease. 15 Improvements in the metabolic status of overweight patients can be achieved by even moderate weight loss: in particular, favorable changes in lipid profiles are observed.…”

Section: Introductionmentioning

confidence: 99%

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Apolipoprotein B signal peptide polymorphism and plasma LDL-cholesterol response to low-calorie diet

Jemaa

Mebazaa

Fumeron³

2004

Int J Obes

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Apolipoprotein B signal peptide polymorphism and plasma LDL-cholesterol response to low-calorie diet

Jemaa

Mebazaa

Fumeron³

2004

Int J Obes

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“…No association was found in a study on the Singapore Chinese population [28], in a Norwegian study on patients with myocardial infarctions versus controls [36] and in other case-control studies of CAD [30,34,35]. In contrast, the Del allele frequency was reported to be significantly higher in CAD patients compared to the control group in the Taiwanese Chinese [7].…”

Section: Apolipoprotein B 5)-ins/del Polymorphismmentioning

confidence: 74%

“…Saha et al [29] reported a value of 0.1958 for Indians in Singapore, but their study was based on a much smaller group. The South Asians (Sikhs) had an expected heterozygosity of 0.3200 [30]. Non-Caucasians, in general, appear to have lower heterozygosities for the 5)-Ins/Del polymorphism compared to the Caucasian populations -0.3941 in the Finns [31], 0.4550 in the French [32], 0.4352 in the Americans [33] and in the Swedes [34], 0.4779 in the Irish [35], and 0.4639 in the Norwegians [36].…”

Section: Apolipoprotein B 5)-ins/del Polymorphismmentioning

confidence: 99%

Apolipoprotein B 5’-Ins/Del and 3’-VNTR Polymorphisms in Chinese, Malay and Indian Singaporeans

Choong

Koay²,

Khaw³

et al. 1999

Hum Hered

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The allele frequencies for the apolipoprotein B (apo B) 5′-Ins/Del and 3′-VNTR polymorphisms varied significantly (p < 0.01) among Singaporeans of Chinese, Malay and Indian descent. We calculated the unbiased expected heterozygosities for the 5′-Ins/Del polymorphism as 0.3357, 0.1984 and 0.2418, and for the 3′-VNTR as 0.5980, 0.5260 and 0.6749, respectively, in the Chinese, Malays and Indians. Compared to heterozygosities reported for other populations, the Singaporeans differed from most Caucasians in having significantly lower values but were closely related to other non-Caucasians. Thirteen alleles, with a bimodal distribution, were observed at the 3′-VNTR polymorphic locus; the alleles occurring most frequently among the Chinese and Malays were of 35 or 53 repeats, and among the Indians, of 37 or 47 repeats. The Del allele was associated with elevated serum cholesterol (p = 0.023), LDL-cholesterol (LDL-C) (p = 0.001) in the Chinese, and apo B (p = 0.007) in the Indians. Likewise, the larger 3′-VNTR alleles (> 41 repeats) were associated with raised cholesterol (p = 0.018), LDL-C (p = 0.025), and triglyceride (p = 0.001) in the Chinese. The two polymorphisms were not in significant linkage disequilibrium (D = –0.0029, p = 0.494) in the three ethnic groups.

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“…Until now, the association studies between apoB polymorphism and lipid phenotypes have reported contradictory results among populations. Generally, apoB diallelic polymorphisms in Asian populations were not associated with lipid levels (20,(30)(31)(32). However, apoB polymorphisms in Caucasian populations show more polymorphic than those in Oriental populations as we described at above.…”

Section: Discussionmentioning

confidence: 80%

The Haplotype Analyses Using Multiple Markers of the Apolipoprotein B Gene in Patients with Coronary Artery Disease

2001

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The high level of low density lipoprotein (LDL) is a risk factor for cardiovascular disease. Apolipoprotein (apo) B is a major protein component of LDL and plays an important role in the maintenance of cholesterol homeostasis. In this study, six polymorphic sites of the apoB gene were anlaysed in 235 patients with coronary artery disease (CAD) and 216 normal control subjects. There were no significant differences in the allele frequencies of apoB polymorphisms between the control and patient groups. However, haplotype frequencies were significantly different between the CAD patients and control (p<0.05). In addition, the allelic distributions of both EcoRI and MspI polymorphisms in Koreans were similar to those in Chinese but significantly different from those in Caucasians. ApoB polymorphisms showed no association with plasma lipid levels. In conclusion, haplotype analysis of the apoB gene using multiple diallelic markers might be a useful marker for Korean CAD patients.

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Apolipoprotein B gene polymorphisms are associated with lipid levels in men of South Asian descent

Cited by 66 publications

References 33 publications

Apolipoprotein B signal peptide polymorphism and plasma LDL-cholesterol response to low-calorie diet

Apolipoprotein B signal peptide polymorphism and plasma LDL-cholesterol response to low-calorie diet

Apolipoprotein B 5’-Ins/Del and 3’-VNTR Polymorphisms in Chinese, Malay and Indian Singaporeans

The Haplotype Analyses Using Multiple Markers of the Apolipoprotein B Gene in Patients with Coronary Artery Disease

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