Apolipoprotein C1 (APOC1) as a novel diagnostic and prognostic biomarker for gastric cancer

Yi, Jie; Ren, Liwen; Wu, Jie; Wan, Li; Zheng, Xiangjin; Du, Guanhua; Wang, Jinhua

doi:10.21037/atm.2019.07.59

Cited by 43 publications

(40 citation statements)

References 38 publications

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“…APOC1 was abnormally expressed in gastric cancer (GC), colorectal cancer (CRC), prostate cancer (PCa), lung cancer, pancreatic cancer, renal cancer and so on. [26][27][28][29][30][31] APOC1 was significantly higher in GC and associated with clinical stage, tumor classification and the lymph node metastasis and overall survival. 26 APOC1 was up-regulated in CRC tissues and tight related to poor prognosis.…”

Section: Dovepressmentioning

confidence: 91%

“…For example, some studies have shown that M2-type macrophages could deliver ApoE through exosomes to promote gastric cancer cell metastasis. [23][24][25] More recent studies of ApoC1's relationship with tumors have been limited to clinical observations, [26][27][28][29][30][31] such as ApoC1 elevations, have been reported more frequently about hormone resistance therapy for prostate cancer, prognosis of TRIPLE plus breast cancer, and aggressive progression of lung cancer. ApoC1 has been reported to promote the proliferation of prostate cancer cells and protect against pancreatic cancer cell apoptosis and so on.…”

Section: Introductionmentioning

confidence: 99%

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<p>Apolipoprotein C1 (APOC1): A Novel Diagnostic and Prognostic Biomarker for Cervical Cancer</p>

Shi¹,

Wang²,

Dai³

et al. 2020

OTT

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Background Previous reports showed that APOC1 was associated with several cancers but the function of APOC1 in cervical cancer was unknown. This study aimed to investigate the clinical effect and function of APOC1 in cervical cancer. Materials and Methods In this study, the relative expression of APOC1 in cervical cancer was detected by RT-qPCR. In order to determine the cell proliferation and migration and invading ability and apoptosis more accurately, we used CCK8 assay, Edu assay, wound healing assay, migration and invasion assay, flow cytometry assay, co-immunoprecipitation, proteomics and Western blot by silencing and overexpressing APOC1 , respectively. The role of APOC1 on tumor progression was explored in vitro and vivo. Results The relative expression of APOC1 in cervical cancer tissues was up-regulated (P<0.05). In cervical cancer cell lines, silencing of APOC1 restrained cell progression and EMT, while over-expression of APOC1 accelerated cell progression and EMT in vivo and vitro (P<0.05). Conclusion APOC1 acts as an oncogene in cervical cancers and knockdown of APOC1 inhibited cervical cancer cells growth in vitro and in vivo. There is a close relationship between the relative expression of APOC1 and clinical outcome in cervical cancer patients.

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Section: Dovepressmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

<p>Apolipoprotein C1 (APOC1): A Novel Diagnostic and Prognostic Biomarker for Cervical Cancer</p>

Shi¹,

Wang²,

Dai³

et al. 2020

OTT

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“…Growing number of evidences have demonstrated the functions of APOC1 in membrane remodeling, cholesterol catabolism, dendritic reorganization and other biological activities [ 10 , 11 ]. Very recently, APOC1 has been identified as a tumor-associated gene involved in the process of human cancers [ 9 , 12 ]. It is recognized that lipid peroxidation is a risk factor for the carcinogenesis of RCC [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein C1 stimulates the malignant process of renal cell carcinoma via the Wnt3a signaling

et al. 2021

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Background Renal cell carcinoma (RCC) is a clinically common tumor in the urinary system, showing an upward trend of both incidence and mortality. Apolipoprotein C1 (APOC1) has been identified as a vital regulator in tumor progression. This study aims to uncover the biological function of APOC1 in RCC process and the underlying mechanism. Methods Differential levels of APOC1 in RCC samples and normal tissues in a downloaded TCGA profile and clinical samples collected in our center were detected by quantitative reverse transcription PCR (qRT-PCR). The prognostic value of APOC1 in RCC was assessed by depicting Kaplan–Meier survival curves. After intervening APOC1 level by transfection of sh-APOC1 or oe-APOC1, changes in phenotypes of RCC cells were examined through CCK-8, colony formation, Transwell assay and flow cytometry. Subsequently, protein levels of EMT-related genes influenced by APOC1 were determined by Western blot. The involvement of the Wnt3a signaling in APOC1-regulated malignant process of RCC was then examined through a series of rescue experiments. Finally, a RCC xenograft model was generated in nude mice, aiming to further clarify the in vivo function of APOC1 in RCC process. Results APOC1 was upregulated in RCC samples. Notably, its level was correlated to overall survival of RCC patients, displaying a certain prognostic value. APOC1 was able to stimulate proliferative, migratory and invasive abilities in RCC cells. The Wnt3a signaling was identified to be involved in APOC1-mediated RCC process. Notably, Wnt3a was able to reverse the regulatory effects of APOC1 on RCC cell phenotypes. In vivo knockdown of APOC1 in xenografted nude mice slowed down the growth of RCC. Conclusions APOC1 stimulates the malignant process of RCC via targeting the Wnt3a signaling.

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“…10 Interestingly, recent studies have shown that the deregulation of APOC1 are detected in some malignancies including breast, gastric and prostate cancer. [10][11][12] Su et al reported that APOC1 overexpressed in prostate cancer (PCa) and APOC1 silencing inhibited cell proliferation, colony formation, cell cycle progression and promoted apoptosis. 12 Furthermore, APOC1 regulates the cell cycle and mediate the proliferation and apoptosis of the cancer cells by controlling the signal pathways for survivin, p21 and capase-3.…”

Section: Introductionmentioning

confidence: 99%

APOC1 is a Potential Prognostic Biomarker and Correlated With Immune Infiltration in ESCC

Xie¹,

Liu²,

Luo³

et al. 2020

Preprint

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PurposeEsophageal cancer (EC) is the sixth leading cause of cancer death worldwide. Esophageal squamous cell carcinoma (ESCC) is a predominant subtype of EC. Identifying diagnostic biomarkers for ESCC is necessary for cancer practice. Increasing evidence illustrates that apolipoprotein C-1 (APOC1) participates in the carcinogenesis. However, the biological function of APOC1 in ESCC remains unclear. Patients and methodsWe investigated the expression level of APOC1 using TIMER2.0 and GEO databases, the prognostic value of APOC1 in ESCC using Kaplan-Meier plotter and TCGA databases. We used LinkedOmics to identify co-expressed genes with APOC1 and perform GO and KEGG pathway analysis. The target networks of kinases, miRNAs and transcription factors were predicted by gene set enrichment analysis (GSEA). The correlations between APOC1 and immune infiltration were calculated using TIMER2.0 and CIBERSORT databases. We further performed the prognostic analysis based on APOC1 expression levels in related immune cells subgroups via Kaplan-Meier plotter database. ResultsAPOC1 was found overexpressed in tumor tissues in multiple ESCC cohorts and high APOC1 expression was related to a dismal prognosis. Multivariate analysis confirmed that APOC1 overexpression was an independent indicator of poor OS. Functional network analysis indicated that APOC1 might regulate the natural killer cell mediated cytotoxicity, phagosome, AMPK and hippo signaling through pathways involving some cancer-related kinases, miRNA and transcription factors. Immune infiltration analysis showed that APOC1 was significantly positively correlated with M0 macrophages cells, M1 macrophages cells and activated NK cells, negatively correlated with regulatory T cells, CD8 T cells, neutrophils and monocytes. High APOC1 expression had a poor prognosis in server immune cells subgroups in ESCC, including decreased CD8+ T cells subgroups. ConclusionThese findings suggest that increased expression of APOC1 is related to poor prognosis and immune infiltration in ESCC. APOC1 holds promise for serving as a valuable diagnostic and prognostic marker in ESCC.

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Apolipoprotein C1 (APOC1) as a novel diagnostic and prognostic biomarker for gastric cancer

Cited by 43 publications

References 38 publications

<p>Apolipoprotein C1 (APOC1): A Novel Diagnostic and Prognostic Biomarker for Cervical Cancer</p>

<p>Apolipoprotein C1 (APOC1): A Novel Diagnostic and Prognostic Biomarker for Cervical Cancer</p>

Apolipoprotein C1 stimulates the malignant process of renal cell carcinoma via the Wnt3a signaling

APOC1 is a Potential Prognostic Biomarker and Correlated With Immune Infiltration in ESCC

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