2022
DOI: 10.1101/2022.08.13.503827
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Apolipoprotein E genotype modulates longitudinal atrophy at the temporal lobe after mild traumatic brain injury

Abstract: Backgrounds: Moderate or severe traumatic brain injury (TBI) is one of the strongest environmental risks for late-life dementia, especially Alzheimer's disease (AD). However, the interaction between genetic factors and environmental exposure to mild TBI triggering neurodegenerative processes is still unclear. We used longitudinal imaging to differentiate spatial patterns of progressive brain volume loss in individual patients with and without carrying apolipoprotein E (APOE) ε4 carriers. Methods: For 59 patien… Show more

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