Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts

Bazrgar, Masood; Karimi, Mehran; Fathzadeh, Mohsen; Senemar, Sara; Peiravian, Farah; Shojaee, Ashraf; Saadat, Mostafa

doi:10.1007/s11033-007-9113-3

Cited by 32 publications

(14 citation statements)

References 32 publications

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“…The APOE genotype frequencies in our study were similar to the frequencies detected in neighbouring populations (Bazrgar et al 2008; Gerdes, Klausen, Sihn, & Faergeman, 1992); they also did not differ significantly from the study by Bloss et al (2010)—the p -value for differences between these two studies was 0.3. The genotype frequencies were also similar to a study conducted in neighbouring Slavonic/Polish population in which the APOE4 allele was associated with elevated risk of Alzheimer disease (Klimkowicz-Mrowiec et al, 2010).…”

Section: Discussionsupporting

confidence: 86%

Lack of an association between left-handedness andAPOEpolymorphism in a large sample of adults: Results of the Czech HAPIEE study

Hubacek

Piper

Pikhart

et al. 2012

Laterality: Asymmetries of Body, Brain and Cognition

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An association between APOE genotype and left-handedness has been previously reported. We examined whether such association exists in a population sample of 4438 unrelated Caucasian adults aged 45–69 years (2022 males and 2416 females). Left-handedness was based on self-reported left-hand dominance for writing (prevalence 4.9%) and on consistently higher left-hand grip strength in two repeated measurements (prevalence 12.2%). Individuals with higher left hand grip strength were seven times more likely to be self-reported left handers (p <.0001, χ2 159.7,2 df). There were no differences in the proportion of self-reported left-handedness (p =.828, χ2 2.1, 5df) or higher grip strength in left hand (p = .557, χ2 3.9, 5 df) between APOE genotypes. The lack of association was similar in both genders and did not differ by age group. The results suggest that left-handedness in adults is not related to APOE genotype.

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Section: Discussionsupporting

confidence: 86%

Lack of an association between left-handedness andAPOEpolymorphism in a large sample of adults: Results of the Czech HAPIEE study

Hubacek

Piper

Pikhart

et al. 2012

Laterality: Asymmetries of Body, Brain and Cognition

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“…Studies in South Koreans and Jamaican Caribbeans established that smaller head circumference and shorter leg length were risk factors for dementia 118,119. Summary compiled from previously published studies 15,18,19,29–31,33–35,37–39,41,42,45–52,54,56,62,65,73,76,101,109,113,115,120–126. MCI=Mild cognitive impairment.…”

Section: Figure and Tablesmentioning

confidence: 99%

Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors

Kalaria

Maestre

Arizaga

et al. 2008

The Lancet Neurology

1,051

739

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Despite mortality due to communicable diseases, poverty, and human conflicts, dementia incidence is destined to increase in the developing world in tandem with the ageing population. Current data from developing countries suggest that age-adjusted dementia prevalence estimates in 65 year olds are high (≥5%) in certain Asian and Latin American countries, but consistently low (1-3%) in India and sub-Saharan Africa; Alzheimer's disease accounts for 60% whereas vascular dementia accounts for ∼30% of the prevalence. Early-onset familial forms of dementia with single-gene defects occur in Latin America, Asia, and Africa. Illiteracy remains a risk factor for dementia. The APOE ε4 allele does not influence dementia progression in sub-Saharan Africans. Vascular factors, such as hypertension and type 2 diabetes, are likely to increase the burden of dementia. Use of traditional diets and medicinal plant extracts might aid prevention and treatment. Dementia costs in developing countries are estimated to be US$73 billion yearly, but care demands social protection, which seems scarce in these regions.

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“…The mean age (SD; min-max) of the patients and the controls were 45.4 (9.8; 23-74) and 44.2 (8.6; 24-72) years, respectively. Because Iranian population is one of the most heterogeneous populations (Bazrgar et al, 2008;Mohamadynejad and Saadat, 2008;Rafiee et al, 2010), we selected our patients and controls from Persian (Caucasians) Muslims living in Fars province. Informed consent was obtained from each subject before the study.…”

Section: Subjectsmentioning

confidence: 99%

Genetic variation in DNA repair gene XRCC7 (G6721T) and susceptibility to breast cancer

Nasiri¹,

Saadat²,

Omidvari³

et al. 2012

Gene

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Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts

Cited by 32 publications

References 32 publications

Lack of an association between left-handedness andAPOEpolymorphism in a large sample of adults: Results of the Czech HAPIEE study

Lack of an association between left-handedness andAPOEpolymorphism in a large sample of adults: Results of the Czech HAPIEE study

Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors

Genetic variation in DNA repair gene XRCC7 (G6721T) and susceptibility to breast cancer

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