Apolipoprotein H, an Acute Phase Protein, a Performing Tool for Ultra-Sensitive Detection and Isolation of Microorganisms from Different Origins

Stefas, Ilias; Dubois, Gérard; Tigrett, Sylvia; Lucarz, Estelle; Veas, Francisco

doi:10.5772/25229

Cited by 5 publications

(6 citation statements)

References 76 publications

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“…In addition, APOH is reportedly an acute-phase protein during HBV infection, and the HBV surface antigen (HBsAg) binds to APOH with high affinity. 21 , 22 , 23 We previously found that HBV and their large surface antigens directly upregulate APOH expression, which inhibits HBsAg secretion and further induces hepatocellular ER stress. 24 , 25 Therefore, we hypothesize that APOH might be a point of convergence between hepatocyte steatosis and HBV-related chronic liver diseases.…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein H induces sex-specific steatohepatitis and gut dysbiosis during chronic hepatitis B infection

Liu¹,

Wu²,

Jiang³

et al. 2023

iScience

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Section: Introductionmentioning

confidence: 99%

Apolipoprotein H induces sex-specific steatohepatitis and gut dysbiosis during chronic hepatitis B infection

Liu¹,

Wu²,

Jiang³

et al. 2023

iScience

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“…However, more work is required to deliver a robust and sensitive diagnosis for patients and clinicians. One possibility is to use innate immune proteins that recognize specific PAMPs, such as Apolipoprotein H linked to paramagnetic beads, to ‘sweep’ a much larger volume of blood [ 209 , 210 , 211 , 212 , 213 ].…”

Section: Borreliaceae Diagnosticsmentioning

confidence: 99%

“…The first Borrelia genome was sequenced in 2008 by Lescot et al [ 241 ]. Since then, researchers have found that Borrelia spirochetes, like Borreliella spp., have a singular linear chromosome and many plasmids [ 209 , 242 , 243 , 244 ]. The Borrelia chromosome is also similar in its GC skew and contains many housekeeping genes [ 241 , 245 ].…”

Section: The Borreliella and Borrelia ...mentioning

confidence: 99%

Large-Scale Sequencing of Borreliaceae for the Construction of Pan-Genomic-Based Diagnostics

Socarras

Haslund-Gourley

Cramer

et al. 2022

Genes

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The acceleration of climate change has been associated with an alarming increase in the prevalence and geographic range of tick-borne diseases (TBD), many of which have severe and long-lasting effects—particularly when treatment is delayed principally due to inadequate diagnostics and lack of physician suspicion. Moreover, there is a paucity of treatment options for many TBDs that are complicated by diagnostic limitations for correctly identifying the offending pathogens. This review will focus on the biology, disease pathology, and detection methodologies used for the Borreliaceae family which includes the Lyme disease agent Borreliella burgdorferi. Previous work revealed that Borreliaceae genomes differ from most bacteria in that they are composed of large numbers of replicons, both linear and circular, with the main chromosome being the linear with telomeric-like termini. While these findings are novel, additional gene-specific analyses of each class of these multiple replicons are needed to better understand their respective roles in metabolism and pathogenesis of these enigmatic spirochetes. Historically, such studies were challenging due to a dearth of both analytic tools and a sufficient number of high-fidelity genomes among the various taxa within this family as a whole to provide for discriminative and functional genomic studies. Recent advances in long-read whole-genome sequencing, comparative genomics, and machine-learning have provided the tools to better understand the fundamental biology and phylogeny of these genomically-complex pathogens while also providing the data for the development of improved diagnostics and therapeutics.

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“…However, APOH has been known to bind with specific to lipoproteins and activate lipoprotein lipase during triglyceride (TG) metabolism, and is closely associated with lipid metabolism [11][12][13][14][15][16][17]. APOH isoforms are associated with the expression levels of TG, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), apolipoproteins B (APOB) and apolipoproteins A (APOA) [18][19][20]. Together, it is interesting to explore the potential regulatory mechanism of APOH in alcohol-associated fatty liver disease in this study.…”

Section: Introductionmentioning

confidence: 99%

Alcohol-dependent downregulation of apolipoprotein H exacerbates fatty liver and gut microbiota dysbiosis in mice

Liu

Zhang

et al. 2022

Lipids Health Dis

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Background Alcohol-related liver disease (ALD) is a major chronic liver ailment caused by alcohol overconsumption and abuse. Apolipoprotein H (APOH) participates in lipid metabolism and might have a potential regulatory role in ALD. Therefore, this study aimed to explore the effects of ApoH on alcohol-induced liver injury and gut microbiota dysbiosis. Methods ApoH−/− mice were generated and the synergic alcoholic steatohepatitis mouse model was constructed, which were used to assess liver function and pathological changes. Results ApoH−/− mice clearly exhibited spontaneous steatohepatitis. Severe hepatic steatosis was observed in alcohol-fed WT and ApoH−/− mice, in which ApoH expression was reduced post alcohol consumption. Moreover, RNA-seq and KEGG pathway analyses indicated that differential expression genes enriched in lipid metabolism and oxidation–reduction process between in alcohol-fed ApoH−/− mice and pair-fed control mice. Finally, gut microbiota diversity and composition were assessed by 16S rRNA Illumina next-generation sequencing. Alpha diversity of enterobacteria was lower in ApoH−/− mice with ethanol feeding than in ethanol-fed WT mice and all control-fed mice (P < 0.05). Moreover, KEGG enrichment analysis, using PICRUSt software, revealed that metabolic functions were activated in the gut microorganisms of ApoH−/− mice with ethanol feeding (P < 0.05). Conclusions Alcohol-downregulated ApoH expression, leading to the progress of fatty liver disease and gut microbiota dysbiosis.

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Apolipoprotein H, an Acute Phase Protein, a Performing Tool for Ultra-Sensitive Detection and Isolation of Microorganisms from Different Origins

Cited by 5 publications

References 76 publications

Apolipoprotein H induces sex-specific steatohepatitis and gut dysbiosis during chronic hepatitis B infection

Apolipoprotein H induces sex-specific steatohepatitis and gut dysbiosis during chronic hepatitis B infection

Large-Scale Sequencing of Borreliaceae for the Construction of Pan-Genomic-Based Diagnostics

Alcohol-dependent downregulation of apolipoprotein H exacerbates fatty liver and gut microbiota dysbiosis in mice

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