Apolipoprotein serum levels related to metabolic syndrome in patients with schizophrenia

Boiko, Anastasiia S.; Mednova, Irina A.; Kornetova, E.; Semke, A.; Бохан, Н. А.; Loonen, Anton J. M.; Ivanova, Svetlana A.

doi:10.1016/j.heliyon.2019.e02033

Cited by 41 publications

(38 citation statements)

References 39 publications

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“…In a previous paper, we observed that apolipoprotein A2 was lower in patients with schizophrenia without MetS, unlike patients with MetS [ 48 ]. Apolipoprotein A2 is the second most abundant protein in high-density lipoproteins and has potent anti-inflammatory effects [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Adipocytokines and Metabolic Syndrome in Patients with Schizophrenia

et al. 2020

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The adipokines leptin, adiponectin, tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) might be associated with metabolic syndrome (MetS) in patients with schizophrenia. In the present study, we attempted to confirm the results of previous reports and assessed their MetS-related correlation with body fat composition and biochemical parameters. We measured in 46 patients with schizophrenia and MetS serum levels of adiponectin insulin, leptin, TNF-α and IL-6 and compared these levels to those of patients with schizophrenia without MetS. The MetS patients had significantly increased leptin levels and leptin/adiponectin ratios, as well as decreased adiponectin levels. Leptin levels correlated with several metabolic parameters, both in patients with and without MetS, including body fat percentage, total fat fold, and body mass index (BMI). Patients without abnormal MetS components had lower levels of leptin and leptin/adiponectin ratios compared with patients who had one or two MetS components. Leptin/adiponectin ratios were higher in patients who had four rather than three MetS components. Multiple regression analysis revealed multiple associations for leptin but only one for adiponectin, TNF-α, and IL-6. Our results support an important pathophysiological role for leptin more than adiponectin in patients with schizophrenia with MetS.

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Section: Discussionmentioning

confidence: 99%

Adipocytokines and Metabolic Syndrome in Patients with Schizophrenia

et al. 2020

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“…The inclusion criteria, criteria for MetS and clinical assessments are described in a previous paper. 14 We included 110 patients with the diagnosis of paranoid schizophrenia verified according to the International Statistical Classification of Diseases, 10th Revision (ICD-10: F20) and who were suffering from an acute relapse. Patients have been divided into groups according to criteria of the International Diabetes Federation (IDF, 2005): 42 patients with MetS and 68 patients without MetS.…”

Section: Patients and Methods Patientsmentioning

confidence: 99%

<p>Cortisol and DHEAS Related to Metabolic Syndrome in Patients with Schizophrenia</p>

Boiko¹,

Mednova²,

Kornetova³

et al. 2020

NDT

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Background: Both dehydroepiandrosterone (DHEAS) and cortisol are secreted by the adrenal glands and may modulate metabolic syndrome (MetS), which often affects the health of patients with schizophrenia. The relationship between the serum levels of these hormones and MetS has not been established. Purpose: In this pilot study, we investigated the serum levels in schizophrenia patients with and without MetS and compared them with those in healthy volunteers. Patients and Methods: After obtaining informed consent, 110 patients with acute paranoid schizophrenia were recruited directly after admission to the Mental Health Research Institute. The control group consisted of 51 persons reported on questioning to be mentally and somatically healthy. Blood samples to prepare serum were drawn after an 8-h overnight fast during one of the first days of admission. Serum cortisol and DHEAS concentrations were quantified by enzyme-linked immunosorbent assay. Results: A total of 42 patients had MetS and 68 patients were without MetS. The cortisol blood level was significantly (p = 0.012) higher in schizophrenia patients without MetS in comparison to healthy controls, while patients with schizophrenia and a MetS have significantly (p = 0.014) lower DHEAS levels than healthy volunteers. These differences could, however, exclusively be attributed to female participants. Analysis of covariance adjusted for gender and age demonstrated a significant relationship between age and DHEAS levels (F = 9.512, р = 0.003). Conclusion: Lower DHEAS serum levels in relationship to MetS become evident in women, but not in men, and have age differences as a confounding factor.

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“…Based on a study on apo levels that showed significant differences of apoA2 and apoC levels in metabolic syndrome, 37 a population sample size of 38 patients was calculated, giving 80% power to detect a difference with a two-sided alpha error of 0.05 (nQuery, Statsol, USA). Descriptive statistics and means±SDs were calculated for all continuous variables in the study.…”

Section: Methodsmentioning

confidence: 99%

apoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetes

Ramanjaneya

Butler

Bashir

et al. 2021

BMJ Open Diab Res Care

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IntroductionPregnant women with gestational diabetes mellitus (GDM) are at risk of adverse outcomes, including gestational hypertension, pre-eclampsia, and preterm delivery. This study was undertaken to determine if apolipoprotein (apo) levels differed between pregnant women with and without GDM and if they were associated with adverse pregnancy outcome.Research design and methodsPregnant women (46 women with GDM and 26 women without diabetes (ND)) in their second trimester were enrolled in the study. Plasma apos were measured and correlated to demographic, biochemical, and pregnancy outcome data.ResultsapoA2, apoC1, apoC3 and apoE were lower in women with GDM compared with control women (p=0.0019, p=0.0031, p=0.0002 and p=0.015, respectively). apoA1, apoB, apoD, apoH, and apoJ levels did not differ between control women and women with GDM. Pearson bivariate analysis revealed significant correlations between gestational age at delivery and apoA2 for women with GDM and control women, and between apoA2 and apoC3 concentrations and C reactive protein (CRP) as a measure of inflammation for the whole group.ConclusionsApoproteins apoA2, apoC1, apoC3 and apoE are decreased in women with GDM and may have a role in inflammation, as apoA2 and C3 correlated with CRP. The fact that apoA2 correlated with gestational age at delivery in both control women and women with GDM raises the hypothesis that apoA2 may be used as a biomarker of premature delivery, and this warrants further investigation.

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Apolipoprotein serum levels related to metabolic syndrome in patients with schizophrenia

Cited by 41 publications

References 39 publications

Adipocytokines and Metabolic Syndrome in Patients with Schizophrenia

Adipocytokines and Metabolic Syndrome in Patients with Schizophrenia

<p>Cortisol and DHEAS Related to Metabolic Syndrome in Patients with Schizophrenia</p>

apoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetes

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