Apoptosis and Chemotherapy for Bladder Cancer

McKnight, J.J.; Gray, Samuel B.; O'Kane, Hugh F.; Johnston, S. R.; Williamson, Kate E.

doi:10.1097/01.ju.0000143194.79287.a9

Cited by 47 publications

(41 citation statements)

References 63 publications

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“…Inducing apoptosis is an important strategy to overcome cancer [36,37,38]. Previous studies proved that activations of caspase-9 and caspase-3 lead to apoptosis in FaDu cells [39,40].…”

Section: Discussionmentioning

confidence: 99%

Deltonin induced both apoptosis and autophagy in head and neck squamous carcinoma FaDu cell

Xie¹,

Fan²,

Jiang³

et al. 2015

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For decades, despite the advancement of medical science, the prognosis of head and neck squamous cell carcinoma (HNSCC), has not improved. Deltonin is one of the major active components of Dioscorea Zingiberensis Wright that has been used for anthrax, rheumatic heart disease, rheumatoid arthritis etc. By employing HNSCC FaDu cell and normal human epidermal keratinocyte, we investigate deltonin efficacy and associated mechanism in both cell culture and nude mice xenografts. Deltonin treatment selectively prevents proliferation of FaDu cells by cell-cycle arrest and induction of apoptosis, via activating checkpoint kinase Chk1and Chk2 as well as caspases 8, 9 and 3. Meanwhile, we found that treatment with deltonin induced autophagy, which played a protective role against deltonin-induced apoptosis. Further studies revealed that deltonin activated autophagy by Akt-mTOR signaling. Additionally, xenograft model showed that administration of deltonin significantly inhibited tumor growth and prolonged survival of tumor bearing mice. Our studies suggested that deltonin might be a potential chemotherapeutic agent against HNSCC, which might contribute to clinical application and pharmacological study of deltonin in future anti-cancer research.

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“…Inducing apoptosis is an important strategy to overcome cancer [36,37,38]. Previous studies proved that activations of caspase-9 and caspase-3 lead to apoptosis in FaDu cells [39,40].…”

Section: Discussionmentioning

confidence: 99%

Deltonin induced both apoptosis and autophagy in head and neck squamous carcinoma FaDu cell

Xie¹,

Fan²,

Jiang³

et al. 2015

neo

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“…27,28 Apoptosis (programmed cell death) results from a cascade of intrinsic and extrinsic signals and depends on the balance between pro-and anti-apoptotic proteins. 34 Caspase-3 is a pro-apoptotic enzyme that has been associated with higher pathologic grade, stage and presence of lymph node metastasis in radical cystectomy specimens. 29 In a study using multiple apoptosis markers to assess their value in improving the accuracy of predicting outcomes for patients with UC, Karam and colleagues demonstrated that loss of caspase-3 was an independent predictor of bladder cancerspecific survival after radical cystectomy.…”

Section: Biomarkers Of Prognosis and Therapeutic Efficacymentioning

confidence: 99%

Personalized medicine in advanced urothelial cancer: when to treat, how to treat and who to treat

Ehdaie

Smith

Theodorescu

2013

CUAJ

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The past decade has provided an improved understanding of the molecular mechanism of bladder cancer by defining distinct pathways in tumorigenesis and progression. Advances in technologies, such as high-throughput transcript profiling, microarrays and proteomics, offer a systematic approach to identifying targets for bladder cancer diagnostics and drug discovery. This review presents a select outline of the advances in the development of biomarkers and targets for patient prognosis and therapy selection. This paper describes a representative cohort of recent studies that have the potential to significantly impact the management of muscle invasive and metastatic urothelial carcinoma of the bladder. Space constraints do not permit this review to be comprehensive and we apologize to the authors whose work we do not cite.

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“…2 Bladder cancer has been shown to resist programmed cell death both with altered expression of pro-and antiapoptotic proteins. [3][4][5] Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has been found to control mitotic progression and induces changes in gene expression that are associated with tumor cell invasiveness. 6,7 Survivin mRNA is selectively expressed during embryonic and fetal development, 8 becomes undetectable or expressed at low levels in most differentiated normal adult tissues, and is overexpressed in human cancers.…”

mentioning

confidence: 99%

Survivin expression is associated with bladder cancer presence, stage, progression, and mortality

Shariat

Ashfaq

Karakiewicz

et al. 2007

Cancer

136

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BACKGROUNDThe purpose was to compare the differential expression of Survivin in normal bladder tissue, bladder transitional cell carcinoma (TCC) of different stages, and to determine whether expression of Survivin is associated with TCC clinical outcomes.METHODSImmunohistochemical staining for Survivin was carried out on archival bladder specimens from 9 normal controls and 222 consecutive patients who underwent radical cystectomy and bilateral lymphadenectomy. Lymph node tissue involved with TCC from 50 of the 222 cystectomy patients was also evaluated.RESULTSSurvivin was expressed in none of the normal bladder specimens, 64% of the cystectomy specimens, and 94% of the malignant lymph nodes. Multivariable analyses performed in the cystectomy patients revealed that Survivin expression was associated with disease recurrence (P = .040), disease‐specific mortality (P = .037), and all‐cause mortality (P = .044).CONCLUSIONSThe findings of the study provide a rationale for further evaluation of Survivin and its downstream signaling pathways in bladder cancer and raise the potential for Survivin‐targeted therapy for bladder cancer. Cancer 2007. © 2007 American Cancer Society.

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Apoptosis and Chemotherapy for Bladder Cancer

Abstract: Much current research in bladder cancer is aimed at restoring chemosensitivity by shifting the cell toward a pro-apoptotic phenotype. Successful translation of this work into clinical practice may improve survival in patients in whom prognosis is currently poor.

Cited by 47 publications

References 63 publications

Deltonin induced both apoptosis and autophagy in head and neck squamous carcinoma FaDu cell

Deltonin induced both apoptosis and autophagy in head and neck squamous carcinoma FaDu cell

Personalized medicine in advanced urothelial cancer: when to treat, how to treat and who to treat

Survivin expression is associated with bladder cancer presence, stage, progression, and mortality

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