“…Esculetin, a coumarin derivative, reportedly has several biological and pharmacological activities, including antioxidant, anti-inflammatory, and antiedema effects [ 22 , 29 ]. Moreover, recent studies have reported the anticancer effects of esculetin against various human cancers, including lung cancer [ 30 , 31 ], colorectal cancer [ 27 , 32 , 33 ], gastric cancer [ 34 ], and leukemia [ 35 , 36 , 37 , 38 ]. In particular, it is noteworthy in the antitumor effect of esculetin in human breast cancer, the counterpart of canine mammary cancer.…”