2004
DOI: 10.1093/carcin/bgh283
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Apoptosis in the development and treatment of cancer

Abstract: Our somatic cells are born by mitosis and almost all will die by apoptosis, a physiological process of cellular suicide. Cancers can occur when this balance is disturbed, either by an increase in cell proliferation or a decrease in cell death. The goal of cancer therapy is to promote the death of cancer cells without causing too much damage to normal cells. Our knowledge of the mechanisms of apoptosis has enhanced our understanding of how some cancers originate and progress. It has also revealed that existing … Show more

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Cited by 345 publications
(242 citation statements)
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References 98 publications
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“…TAM is a front-line endocrine therapeutic drug for ER-positive breast cancers. Results from TAM therapy showed a 40-50% reduction in the risk of cancer recurrence and cancer mortality (2). Recently, TAM has been demonstrated to be effective for some ER-negative breast cancers, as well as other types of cancers, including gliomas.…”
Section: Introductionmentioning
confidence: 99%
“…TAM is a front-line endocrine therapeutic drug for ER-positive breast cancers. Results from TAM therapy showed a 40-50% reduction in the risk of cancer recurrence and cancer mortality (2). Recently, TAM has been demonstrated to be effective for some ER-negative breast cancers, as well as other types of cancers, including gliomas.…”
Section: Introductionmentioning
confidence: 99%
“…In recent years, the idea that tumour cells treated with cytotoxic drugs or radiation die owing to apoptosis (programmed cell death), as opposed to the direct effect of the treatment itself, has become widely accepted (Barry et al, 1990;Reed et al, 1994;Aldridge and Radford, 1998;Ferreira et al, 2002;Jazirehi et al, 2003;Okada and Mak, 2004). There are, however, a few persuasive skeptics (Brown and Wouters, 1999;Steel, 2001;Gerl and Vaux, 2005). We have begun to investigate the mechanism of cell death induced by radiolabelled antibodies (Abs), primarily using radionuclides emitting low-energy electrons (some Auger and conversion electrons) (Griffiths et al, 1999;Ong et al, 2001).…”
mentioning
confidence: 99%
“…Some new anticancer drugs are specifically designed to activate apoptosis, and probably act via this mechanism (Gerl and Vaux, 2005). However, in regard to classical cytotoxic drugs and radiation, some re-evaluation of the literature, based on the factors described herein, may be required in order to correctly understand the mechanism of cell death.…”
mentioning
confidence: 99%
“…Salah satu bentuk kematian sel yang mudah dideteksi dan sering dievaluasi adalah apoptosis. Apoptosis merupakan programmed cell death yaitu mekanisme homeostatis untuk memelihara populasi sel dalam jaringan tubuh Gerl & Vaux (2005). Apoptosis dapat diaktifkan dan dinonaktifkan oleh berbagai gen. Deregulasi gen yang terlibat dalam aktivasi atau eksekusi pada proses apoptosis dapat menyebabkan radioresistensi sel (Tanaka & Harima, 2000).…”
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“…Gen MDM2 pada awalnya diidentifikasi sebagai satu dari tiga gen (MDM 1, 2, dan 3) (Gerl & Vaux, 2005;Iwakuma & Lozano, 2003). Gen MDM2 pada manusia memiliki panjang 491 asam amino dan berinteraksi dengan domain N terminal pada α heliks transaktivasi p53 Shangary & Wang (2008).…”
unclassified