Apoptosis in transitional cell carcinoma of bladder and its relation to proliferation and expression of P53 and Bcl-2

Amirghofran, Zahra; Monabati, Ahmad; Khezri, Abdolaziz; Malek-Hosseini, Zahra

doi:10.1007/bf03033744

Cited by 12 publications

(5 citation statements)

References 25 publications

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“…Bcl-2, though associated with a better RFS, correlated with p53 accumulation, strongly suggesting complex interactions, which are reflected in the conflicting results on its prognostic impact obtained in different studies [14,36,37] . PCNA, though associated with Ki-67 expression, predicted a better RFS in high-grade tumors, which may be due to the interaction with other molecules, such as p21, modulating its functional activity [38] .…”

Section: Discussionmentioning

confidence: 97%

Large-Scale Analysis of Cell Cycle Regulators in Urothelial Bladder Cancer Identifies p16 and p27 as Potentially Useful Prognostic Markers

Brunner

Verdorfer

Prelog³

et al. 2008

Pathobiology

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Aims: We investigated the value of multiple cell cycle markers for their prognostic impact on overall survival and recurrence-free survival in urothelial carcinoma (UC). Methods: A tissue microarray consisting of 99 UCs was evaluated for the expression of p53, p16, p21, p27, cyclin D1, cyclin E , Bcl-2, Ki-67 and PCNA. Statistical analysis was performed applying Kaplan-Meier and Cox regression models using receiver operator characteristic curves for determination of markers’ cutoffs. Results: Expression above the cutoffs of Ki-67, p53 and p27, particularly in high-grade and early-stage UC, was associated with worse overall survival, while expression of p16 indicated a better outcome in low-grade and low-stage tumors. Recurrence-free survival was better in patients with high-grade UC expressing PCNA, p16 and cyclin E, and low-grade UC expressing Bcl-2 above the cutoffs, but worse in all tumors with high Ki-67. Conclusion: Cell cycle deregulation in UC is complex and the prognostic value of the various involved proteins should be differentially regarded with respect to this complexity and other tumor characteristics such as grade and stage. Our results point towards the role of p16- and p27-associated pathways in tumor progression and indicate that, by using standardized approaches for tissue antigen expression, evaluation and cutoff determination, single potentially useful prognostic markers could be identified.

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Section: Discussionmentioning

confidence: 97%

Large-Scale Analysis of Cell Cycle Regulators in Urothelial Bladder Cancer Identifies p16 and p27 as Potentially Useful Prognostic Markers

Brunner

Verdorfer

Prelog³

et al. 2008

Pathobiology

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“…Outside of our panel of biomarkers, there are several other exploratory markers that might be worth further research; these include: p21 [2,12,14,19], Her‐2 [72–75], Bax/bcl‐2 [76–79] and CD40 [80,81]. Epigenetic processes, such as DNA methylation and histone acetylation, also represent important mechanisms in carcinogenesis [4,5].…”

Section: Other Markersmentioning

confidence: 99%

Biomarkers in bladder cancer

Bryan¹,

Zeegers

James

et al. 2010

BJU International

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Detailed molecular insights into bladder cancer biology might allow more detailed prognostication and optimization of treatment with the objective of improving patient outcome and quality of life. However, in bladder cancer research the search for biomarkers has been called into question and has even obtained notoriety. It is unlikely that any single marker will be able to improve prognostication for patients with bladder cancer above and beyond grade and stage, but a combination of multiple independent markers might more precisely predict the outcome. From a previous review, we identified seven biomarkers to study within the setting of the Bladder Cancer Prognosis Programme (BCPP), a 5‐year multicentre programme of research based at the University of Birmingham and funded by Cancer Research UK, investigating their effectiveness in predicting recurrence and progression. As part of the ongoing quality‐assurance process for BCPP we present an updated review of our selected biomarkers, as well as highlighting other recent important developments in bladder cancer research.

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“…На 30-й день после инъекции ретинограммы всех исследуемых групп не отличались от нормы, исследуемые наночастицы с хитозан-гликолем не оказали токсического влияния на сетчатку. Это исследование является показательным для дальнейшей разработки транспортных систем на основе хитозана для генной терапии заболеваний пигментного эпителия сетчатки [49]. M. De la Fuente et al (2008) исследовали эффективность и потенциал наночастиц хитозана с гиалуроновой кислотой в качестве носителей генов для местной терапии глазных заболеваний.…”

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“…При изучении процессов пролиферации и апоптоза А. Monabati с соавт. выявили, что индекс апоптоза имеет связь со степенью дифференцировки опухоли [49]. При поверхностном РМП гиперэкспрессия р53 и Ki-67 связана со снижением степени дифференцировки и повышением частоты локальных рецидивов [8,23,54].…”

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Учредители: ГБОУ ВПО «Красноярский государственный медицинский университет им. проф. В. Ф. Войно-Ясенецкого» Министерства здравоохранения РФ. ФГБНУ «Научно-исследовательский Институт медицинских проблем Севера» Главный редактор д. м. н., профессор И. П. Артюхов Зам. главного редактора: д. м. н., профессор М. М. Петрова д. м. н., профессор Л. М. Куртасова Первый номер журнала «Сибирское медицинское обозрение» вышел в свет в 1918 году. Это был первый медицинский журнал в Сибири. У истоков его стояли известные деятели в области клинической медицины, общественного здоровья и здравоохранения Красноярска В. М. Крутовский, П. И. Мажаров, Р. К. Пикок, П. Н. Коновалов и другие. Журнал возрожден в 2001 году по решению Ученого совета КрасГМА.

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Apoptosis in transitional cell carcinoma of bladder and its relation to proliferation and expression of P53 and Bcl-2

Cited by 12 publications

References 25 publications

Large-Scale Analysis of Cell Cycle Regulators in Urothelial Bladder Cancer Identifies p16 and p27 as Potentially Useful Prognostic Markers

Large-Scale Analysis of Cell Cycle Regulators in Urothelial Bladder Cancer Identifies p16 and p27 as Potentially Useful Prognostic Markers

Biomarkers in bladder cancer

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