Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids

Euphorbia Diterpenes: Isolation, Structure, Biological Activity, and Synthesis (2008–2012)

“…47 One group of them is the diterpenes, isolated from different Euphorbia species. Unfortunately, the knowledge on the mechanism of action, on a molecular basis, is still missing.…”

“…47 Resistance to apoptosis may be a major factor for the ineffectiveness of cancer treatment. Investigation of the apoptosis-inducing mechanism of 17-hydroxyjolkinolide B (HJB) revealed that HJB strongly inhibits IL-6-induced and constitutive STAT3 (signal transducer and activator of transcription) activation.…”

Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures

“…Recently, considerable attention has been devoted to known compounds jatrophane and lathyrane type which are non-phorboid structures, but have been considered to be potent modulators of MDR. [10][11][12][13][14][15][16][17][18] However, a few types of lathyrane diterpenes were found and only the different substitutions related to anti-MDR bioactivity were focused. 15 The structure-activity relationship has not been elaborated from the aspect of different skeletons.…”

Perspectives in Cancer Chemotherapy, in vitro and in vivo Experiments

“…Three of the tested diterpene derivatives (6, Many classes of antitumour drugs, including naturally occurring and pharmaceutical compounds, induce apoptosis in cancer cell (15,16). Apoptosis is typically induced by the activation of membrane receptors, cell cycle arrest, p53 activation by DNA damaging agents and mitochondria pore transition permeability (11).…”

“…Several studies have shown that most chemotherapeutic agents exert their anticancer activity by inducing programmed cell death, which is an essential physiological process required to eliminate abnormal cells (15)(16)(17). Compounds, which regulate and overcome the apoptosis deficiency of cancer cells, are of great therapeutic importance, and the development of apoptosis-modulating agents has become an important approach for the discovery of new antitumour drugs.…”