Apoptosis-promoting and migration-suppressing effect of alantolactone on gastric cancer cell lines BGC-823 and SGC-7901 via regulating p38MAPK and NF-κB pathways

Yin, He; Cao, Xiangyu; Kong, Yuchi; Wang, S; Xia, Ying; Bi, Ruochen; Liu, J

doi:10.1177/0960327119855128

Cited by 21 publications

(17 citation statements)

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“…alT is the main biologically active compound derived from Inula helenium (42). alT has been widely researched as a potential candidate for the treatment of several types of cancer, and previous in vivo studies have reported its antiproliferative, anti-metastatic and anti-invasive activity in a variety of cell lines (19,20,42). The present study aimed to evaluate the effect of alT on osteosarcoma and to determine whether it could be used as a potential future treatment strategy for this disease.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that alT promotes numerous biological effects, including anti-inflammatory and antioxidant functions (18,19). it has also been observed to suppress several types of human cancer, including gastric, pancreatic and breast cancer cells (19)(20)(21). it is reported that these anticancer effects of alT are mediated through the Pi3K/aKT signaling pathway (22).…”

Section: Introductionmentioning

confidence: 99%

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Alantolactone suppresses human osteosarcoma through the PI3K/AKT signaling pathway

et al. 2019

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osteosarcoma is the most common type of malignant bone cancer and results in cancer-related deaths among adolescents. alantolactone (alT) demonstrates antitumor properties in various diseases; however, its potential role in osteosarcoma is relatively unclear. The aim of the present study was to evaluate the effect of alT on osteosarcoma. alT significantly decreased the viability of U2OS and HOS osteosarcoma cell lines. Cells flow cytometry assay and Hoechst 33258 staining assay revealed that ALT significantly increased the proportion of apoptotic u2oS cells. in addition, wound healing and Transwell invasion assays demonstrated that the invasion and migration of osteosarcoma were markedly reduced upon alT treatment. it was hypothesized that the antitumor functions of alT are mediated through inhibition of the Pi3K/aKT signaling pathway. in conclusion, the results of the present study confirmed the inhibition of ALT on osteosarcoma cells via downregulation of Pi3K/aKT signaling pathways, suggesting alT as a potential therapeutic candidate for osteosarcoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alantolactone suppresses human osteosarcoma through the PI3K/AKT signaling pathway

et al. 2019

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“…Although alantolactone is associated with allergic contact dermatitis triggered by Inula species [33][34][35], this compound was first described as anti-helminthic [36], with subsequent studies demonstrating its tremendous potential, mainly as antitumor [37][38][39][40], anti-inflammatory [26,41], and antioxidant [42] agent.…”

Section: Alantolactonementioning

confidence: 99%

Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases

et al. 2020

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Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species, exhibit a broad spectrum of biological effects and several of them are already commercially available, such as artemisinin. Here the most recent and impactful results of in vivo, preclinical and clinical studies involving a selection of ten sesquiterpene lactones (alantolactone, arglabin, costunolide, cynaropicrin, helenalin, inuviscolide, lactucin, parthenolide, thapsigargin and tomentosin) are presented and discussed, along with some of their derivatives. In the authors’ opinion, these compounds have been neglected compared to others, although they could be of great use in developing important new pharmaceutical products. The selected sesquiterpenes show promising anticancer and anti-inflammatory effects, acting on various targets. Moreover, they exhibit antifungal, anxiolytic, analgesic, and antitrypanosomal activities. Several studies discussed here clearly show the potential that some of them have in combination therapy, as sensitizing agents to facilitate and enhance the action of drugs in clinical use. The derivatives show greater pharmacological value since they have better pharmacokinetics, stability, potency, and/or selectivity. All these natural terpenoids and their derivatives exhibit properties that invite further research by the scientific community.

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“…It has different effects on different tumor cells, and even plays completely opposite effects. There was evidence demonstrating that the phosphorylation of p38 was signi cantly upregulated in gastric cancer cells when treated with alantolactone, that promoting apoptosis and mitigating migration and invasion [17]. Likewise, the p38MAPK pathway regulates the apoptosis in osteosarcoma cells [18,19] and esophageal cancer cells [20].…”

Section: Discussionmentioning

confidence: 99%

A prognostic risk model constructed by proteins in predicting prognosis for ovarian cancer

Yan

Niu

2021

Preprint

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BackgroundsOvarian cancer is the most lethal malignant tumor in gynecological cancers worldwide. Approximately 70% of patients have a poor prognosis, who experienced progression or recurrence within 5 years. The aim of this study attempts is to screen out the potential prognosis-related proteins and establish a prognostic risk model for predicting the prognostic risk for patients with ovarian cancer.MethodData were obtained from the Cancer Proteome Atlas (TCPA) and the Cancer Genome Atlas (TCGA). The proteins significantly related to survival risk in ovarian cancer patients were screened out by Kaplan-Meier test and COX regression analysis. A prognostic risk model was constructed based on the optimal proteins selected by multivariate Cox analysis. The prognostic risk model was validated in different clinical characteristics. The sankyl diagram was used to visualize the relationship between the prognosis-related proteins and their co-expression proteins.ResultsA prognostic risk model consisting of seven proteins that significantly related to prognosis was established. Patients with high risk score were associated with poor survival and relative protein expression. In the multivariate cox regress analysis, only age and the risk score were the independence prognosis factors. The AUC for the risk score was 0.721 in ROC curve for patients under 70 years old. Pearson’s correlation analysis showed that 25 co-expression proteins correlated with the prognosis-related proteins.ConclusionOur study demonstrated that a novel prognostic risk model constructed by proteins could predict prognosis for patients with ovarian cancer.

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Apoptosis-promoting and migration-suppressing effect of alantolactone on gastric cancer cell lines BGC-823 and SGC-7901 via regulating p38MAPK and NF-κB pathways

Cited by 21 publications

References 50 publications

Alantolactone suppresses human osteosarcoma through the PI3K/AKT signaling pathway

Alantolactone suppresses human osteosarcoma through the PI3K/AKT signaling pathway

Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases

A prognostic risk model constructed by proteins in predicting prognosis for ovarian cancer

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