“…On the contrary, (pre‐)clinical trials including non‐steroidal anti‐inflammatory drugs (NSAIDs) suggested that inhibiting the immune system may also be of benefit in reducing the disease incidence or slowing down AD progression (Stewart et al , ; Anthony et al , ; in t' Veld et al , ; Zandi et al , ; Monsonego & Weiner, ; Heneka et al , ; Yip et al , ). Additionally, microglia can be activated by Αβ resulting in secretion of inflammatory cytokines that can harm neurons and provoke toxicity (Meda et al , ; Giulian et al , ; Combs et al , ; Manocha et al , ). It is therefore not clear whether microglial activation is beneficial or detrimental for disease progression (Morgan et al , ; Wyss‐Coray, ; Gandy & Heppner, ).…”