Apparent diffusion coefficient of intervertebral discs related to matrix composition and integrity

Antoniou, John; Demers, Caroline N.; Beaudoin, G.; Goswami, Tapas; Mwale, Fackson; Aebi, Max; Alini, Mauro

doi:10.1016/j.mri.2004.02.011

Cited by 101 publications

(92 citation statements)

References 36 publications

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“…Similar quantitative imaging studies investigating intervertebral disc degeneration have been performed previously, including T 1 -and T 2 -weighted relaxation [4,8,11], magnetization transfer [27], diffusion imaging [3,15,18,21], and spectroscopy [19,22]. Some techniques, while appropriate for basic science research, are less suitable for clinical in vivo applications.…”

Section: Discussionmentioning

confidence: 86%

In vivo quantification of human lumbar disc degeneration using T1ρ-weighted magnetic resonance imaging

et al. 2006

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Section: Discussionmentioning

confidence: 86%

In vivo quantification of human lumbar disc degeneration using T1ρ-weighted magnetic resonance imaging

et al. 2006

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“…The uncoupling of the correlation between T 2 and ADC in tumours supports this finding of added value when DW MRI is used together with T 2 W imaging for tumour detection. Ultrastructural features of tumours that may contribute to reduced diffusivity but not to T 2 include macromolecules such as proteoglycans [22] or glycosaminoglycans [23] in the extracellular matrix.…”

Section: Discussionmentioning

confidence: 99%

Relationship betweenT₂relaxation and apparent diffusion coefficient in malignant and non-malignant prostate regions and the effect of peripheral zone fractional volume

Simpkin

Morgan²,

Giles³

et al. 2013

BJR

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Objective: To establish whether T 2 relaxation and apparent diffusion coefficient (ADC) in normal prostate and tumour are related and to investigate the effects of glandular compression from an enlarged transition zone (TZ) on peripheral zone (PZ) T 2 and ADC by correlating them with the peripheral zone fractional volume (PZFV).Methods: 48 consecutive patients prospectively underwent multiecho T 2 weighted (T 2 W) (echo times 20, 40, 60, 80, 100 ms) and diffusion-weighted (b50, 100, 300, 500, 800 s mm 22 ) endorectal MRI. In 43 evaluable patients, single slice whole PZ, TZ and tumour (focal hypointense signal on T 2 W images in a biopsy-positive octant) regions of interest were transferred to T 2 and ADC maps by slice matching. T 2 and ADC values were correlated, and PZ values were correlated with PZFV.

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“…The center of the nucleus pulposus contains only low number of fibers; therefore, significant changes of the diffusivity cannot be expected. Antoniou et al (20) reported on correlations between ADC values and age, and ADC and degeneration of IVD, respectively. Decreases in water and glycosaminoglycan contents in the NP resulted in decreases of ADC values.…”

Section: Discussionmentioning

confidence: 99%

T2‐ and diffusion‐maps reveal diurnal changes of intervertebral disc composition: An in vivo MRI study at 1.5 Tesla

Ludescher¹,

Effelsberg

Martirosian³

et al. 2008

Magnetic Resonance Imaging

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Purpose: To investigate the lumbar intervertebral discs (IVDs) by MRI in the morning and evening after a diurnal load cycle. Changes in MR characteristics (T2-weighted imaging, T2-and apparent diffusion coefficient [ADC] -mapping) during the course of the day were visualized and analyzed visually and quantitatively. The length of the lumbar spine was measured in between the lower anterior edge of Th12 and the upper anterior edge of S1. T2 changes and diffusion characteristics of the vertebral disc tissue were investigated with a higher spatial resolution than in former studies. Materials and Methods:In six males, lumbar IVDs were investigated in the morning and evening. T2-maps and ADC maps were generated. Data were analyzed by selecting regions of interest (ROI) in the annulus fibrosus (AF), nucleus pulposus (NP), and an intermediate area.Results: From morning to evening, T2 decreased in the center of the NP (Ϫ7.9%; P ϭ 0.001) and the intermediate voxels (Ϫ6.4%; P Ͻ 0.0005). T2 increased (8.5%; P Ͻ 0.048) in the AF. ADC decreased in the AF (Ϫ5.2%; P ϭ 0.007) and the intermediate ROIs (Ϫ2.2%; P ϭ 0.004). There was no significant change of ADC in the NP (Ϫ1.6%; P ϭ 0.242).Conclusion: T2 and diffusion (ADC) changes of IVDs in humans were investigated with a spatial differentiation between NP and AF. T2 and ADC turned out to be sensitive parameters in investigating changes in the MR characteristics of the IVD matrix during a day. Highly resolved MR imaging and parameter mapping is expected to be an interesting tool in characterizing structural changes in the vertebral disc architecture in an early stage of degeneration.

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Apparent diffusion coefficient of intervertebral discs related to matrix composition and integrity

Cited by 101 publications

References 36 publications

In vivo quantification of human lumbar disc degeneration using T1ρ-weighted magnetic resonance imaging

In vivo quantification of human lumbar disc degeneration using T1ρ-weighted magnetic resonance imaging

Relationship betweenT₂relaxation and apparent diffusion coefficient in malignant and non-malignant prostate regions and the effect of peripheral zone fractional volume

T2‐ and diffusion‐maps reveal diurnal changes of intervertebral disc composition: An in vivo MRI study at 1.5 Tesla

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Apparent diffusion coefficient of intervertebral discs related to matrix composition and integrity

Cited by 101 publications

References 36 publications

In vivo quantification of human lumbar disc degeneration using T1ρ-weighted magnetic resonance imaging

In vivo quantification of human lumbar disc degeneration using T1ρ-weighted magnetic resonance imaging

Relationship betweenT2relaxation and apparent diffusion coefficient in malignant and non-malignant prostate regions and the effect of peripheral zone fractional volume

T2‐ and diffusion‐maps reveal diurnal changes of intervertebral disc composition: An in vivo MRI study at 1.5 Tesla

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Relationship betweenT₂relaxation and apparent diffusion coefficient in malignant and non-malignant prostate regions and the effect of peripheral zone fractional volume