Apparent Diffusion Coefficients of Metabolites in Patients with MELAS Using Diffusion-Weighted MR Spectroscopy

Liu, Z.; Zheng, Dandan; Wang, X.; Zhang, J.; Xie, Shusen; Xiao, Jiangxi; Xue-xiang, Jiang

doi:10.3174/ajnr.a2395

Cited by 18 publications

(11 citation statements)

References 41 publications

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“…This allowed us to more accurately estimate tissue‐specific metabolite ADC values and in particular metabolite ADC in GM, whereas previous studies (including our own) reported values obtained from large VOIs where partial volume of WM is unavoidable. In our study, GM metabolite ADC values of all three metabolites were lower than values reported previously . Values reported previously for metabolite ADC in WM (e.g., for tNAA) are comparable to those reported here .…”

Section: Discussionsupporting

confidence: 81%

Diffusion‐weighted chemical shift imaging of human brain metabolites at 7T

Ercan

Techawiboonwong

Versluis

et al. 2014

Magnetic Resonance in Med

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Section: Discussionsupporting

confidence: 81%

Diffusion‐weighted chemical shift imaging of human brain metabolites at 7T

Ercan

Techawiboonwong

Versluis

et al. 2014

Magnetic Resonance in Med

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“…More recently, NAA radial ADC was found to increase in schizophrenia (~20%), accompanied by reduced myelin content, indicating axonal abnormalities in this disease (34). In patients with mitochondrial neuronopathy (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes, termed as MELAS), drastic increases of ADCs of NAA (67%), tCr (50%), and Cho (50%) were observed in the normal-appearing frontal grey matter as well as the lesion regions, demonstrating that MELAS involves the entire brain (51). Aging-related intracellular diffusion environment changes may also affect brain metabolite ADCs, as shown by a recent study where NAA, Cr, and Cho ADCs decreased in healthy elder volunteers when compared with those in young controls (50).…”

Section: Diffusion Mrs In Pathological Brainsmentioning

confidence: 99%

In vivo diffusion MRS investigation of non‐water molecules in biological tissues

Cao¹,

2016

NMR in Biomedicine

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Diffusion MRS of non-water molecules offers great potential in directly revealing various tissue microstructures and physiology at both cellular and subcellular levels. In brain, H diffusion MRS has been demonstrated as a new tool for probing normal tissue microstructures and their pathological changes. In skeletal muscle, H diffusion MRS could characterize slow and restricted intramyocellular lipid diffusion, providing a sensitive marker for metabolic alterations, while P diffusion MRS can measure ATP and PCr diffusion, which may reflect the capacity of cellular energy transport, complementing the information from frequently used P MRS in muscle. In intervertebral disk, H diffusion MRS can directly monitor extracellular matrix integrity by quantifying the mobility of macromolecules such as proteoglycans and collagens. In tumor tissue, C diffusion MRS could probe intracellular glycolytic metabolism, while H diffusion MRS may separate the spectrally overlapped lactate and lipid resonances. In this review, recent diffusion MRS studies of these biologically relevant non-water molecules under normal and diseased conditions will be presented. Technical considerations for diffusion MRS experiments will be discussed. With advances in MRI hardware and diffusion methodology, diffusion MRS of non-water molecules is expected to provide increasingly valuable and biologically specific information on tissue microstructures and physiology, complementing the traditional diffusion MRI of small and ubiquitous water molecules. Copyright © 2016 John Wiley& Sons, Ltd.

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“…Previous observations have provided strong evidence for the important physiological role of the CK system for normal brain function, and suggested that energy dysfunction processes are crucially related to cell death not only in neurodegenerative disorders but even in normal aging (Andres, et al, 2008). So far, DW-MRS has been applied to study normal aging (Zheng, et al, 2012) as well as disease pathophysiology in brain tumors (Colvin, et al, 2008,Harada, et al, 2002, acute cerebral ischemia (Harada, et al, 2002,Zheng, et al, 2012, multiple sclerosis (Wood, et al, 2012), psychiatric disorders (Du, et al, 2013), and mitochondrial cytopathies (Liu, et al, 2011). Here we employed DW-MRS in combination with DTI in order to separately detect and quantify intra-axonal damage and demyelination in healthy aging in the anterior body of the corpus callosum (CC).…”

Section: Introductionmentioning

confidence: 99%

Differentiating between axonal damage and demyelination in healthy aging by combining diffusion-tensor imaging and diffusion-weighted spectroscopy in the human corpus callosum at 7 T

Branzoli

Ercan

Valabrègue

et al. 2016

Neurobiology of Aging

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Diffusion-tensor imaging and single voxel diffusion-weighted magnetic resonance spectroscopy were used at 7T to explore in vivo age-related microstructural changes in the corpus callosum. Sixteen healthy elderly (age range 60-71 years) and 13 healthy younger controls (age range 23-32 years) were included in the study. In healthy elderly, we found lower water fractional anisotropy and higher water mean diffusivity and radial diffusivity in the corpus callosum, indicating the onset of demyelination processes with healthy aging. These changes were not associated with a concomitant significant difference in the cytosolic diffusivity of the intra-axonal metabolite N-acetylaspartate (p = 0.12), the latter representing a pure measure of intra-axonal integrity. It was concluded that the possible intra-axonal changes associated with normal aging processes are below the detection level of diffusion-weighted magnetic resonance spectroscopy in our experiment (e.g., smaller than 10%) in the age range investigated. Lower axial diffusivity of total creatine was observed in the elderly group (p = 0.058), possibly linked to a dysfunction in the energy metabolism associated with a deficit in myelin synthesis.

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Apparent Diffusion Coefficients of Metabolites in Patients with MELAS Using Diffusion-Weighted MR Spectroscopy

Cited by 18 publications

References 41 publications

Diffusion‐weighted chemical shift imaging of human brain metabolites at 7T

Diffusion‐weighted chemical shift imaging of human brain metabolites at 7T

In vivo diffusion MRS investigation of non‐water molecules in biological tissues

Differentiating between axonal damage and demyelination in healthy aging by combining diffusion-tensor imaging and diffusion-weighted spectroscopy in the human corpus callosum at 7 T

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