Apparent ?inhibition? as tested by means of the dilution curve system in patients with clotting defect due to liver damage

Abstract

At equivalent Thrombotest basal values on undiluted non-contacted plasma, there is no difference between coumarin plasma and liver damage plasma in the dilution curve system. A hemophilia BM plasma with longer basal clotting times yielded a much flatter curve and a very large "inhibitory" effect (greater than 6 Units). A coumarin plasma with the same basal Thrombotest clotting times as Hemophilia BM plasma, namely 100 seconds, yielded a much steeper curve and a very low inhibition (0.7 Units). These findings are against the presence of inhibitors in coumarin or liver damage plasmas.