Applicability and Prognostic Value of the New TNM Classification System in 135 Patients With Primary Cutaneous Anaplastic Large Cell Lymphoma

Benner, Marchina F.; Willemze, Rein

doi:10.1001/archdermatol.2009.280

Cited by 97 publications

(105 citation statements)

References 15 publications

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“…Given the higher incidence of cALCL in adults, most published series analyzing ALK expression have included predominately adult patients. 23 There have been only single case reports and small series of pediatric cALCL, and in these ALK staining was inconsistently performed. [24][25][26][27][28] We assume that our series is not population-based as cutaneous CD30 + LPD are diagnosed and treated either by dermatologists or pediatric oncologists.…”

Section: Discussionmentioning

confidence: 99%

ALK-positive anaplastic large cell lymphoma limited to the skin: clinical, histopathological and molecular analysis of 6 pediatric cases. A report from the ALCL99 study

et al. 2012

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Anaplastic large cell lymphomas are peripheral T-cell lymphomas that are characterized by a proliferation of large anaplastic blasts expressing CD30. In children, systemic anaplastic large cell lymphomas often present at advanced clinical stage and harbor translocations involving the anaplastic lymphoma kinase (ALK) gene leading to the expression of chimeric anaplastic lymphoma kinase (ALK)-fusion proteins. Primary cutaneous anaplastic large cell lymphoma is regarded as an ALK-negative variant confined to the skin and is part of the spectrum of primary cutaneous CD30-positive T-cell lymphoproliferative disorders. Thirty-three of 487 pediatric patients registered within the Anaplastic Large Cell Lymphoma-99 trial (1999 to 2006) presented with a skin limited CD30-positive lymphoproliferative disorder. In 23 of the 33 patients, material for international histopathological review was available, and the cases were studied for histopathological, immunophenotypical and clinical features as well as for breaks within the ALK gene. Five of 23 cases and one additional case (identified after closure of the trial) expressed ALKprotein. Complete staging excluded any other organ involvement in all children. Expression of ALK proteins was demonstrated by immunohistochemistry in all cases and the presence of breaks of the ALK gene was genetically confirmed in 5 evaluable cases. The histopathological and clinical picture of these skin-restricted ALK-positive lymphomas was indistinguishable from that of cutaneous anaplastic large cell lymphoma. Five children presented with a single skin lesion that was completely resected in 4 and incompletely resected in one. Three of these patients received no further therapy, 2 additional local radiotherapy, and one chemotherapy. All children remain in complete remission with a median follow up of seven years (range 1-8 years). We present 6 pediatric cases of ALK-positive primary cutaneous anaplastic large cell lymphomas. After thorough exclusion of systemic involvement, therapy confined to local measures seems to be sufficient to induce cure. ©2013 Ferrata Storti Foundation. This is an open

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Section: Discussionmentioning

confidence: 99%

ALK-positive anaplastic large cell lymphoma limited to the skin: clinical, histopathological and molecular analysis of 6 pediatric cases. A report from the ALCL99 study

et al. 2012

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“…2 Although LyP has a chronic course with recurrent self-healing papulonodular lesions, PCALCL manifests as rapidly growing and ulcerating skin tumors, 2 and .20% of patients with multifocal skin involvement die within 5 years. 3 Despite its usual indolent clinical behavior, LyP is associated with the development of second malignant lymphoma in nearly 20% of patients, including PCALCL and mycosis fungoides (MF). 4 Although not considered to be a CD30 1 LPD, MF may develop CD30 1 T cells, especially in the setting of largecell transformation (MF-LCT), which manifests a more aggressive clinical course.…”

Section: Primary Cutaneous Cd30mentioning

confidence: 99%

SATB1 overexpression promotes malignant T-cell proliferation in cutaneous CD30+ lymphoproliferative disease by repressing p21

Wei

Zhang

et al. 2014

Blood

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“…Cutaneous relapses are common, but extracutaneous dissemination occurs in only 10% to 15% of patients and mainly involves regional lymph nodes. [2][3][4] LyP is characterized by a chronic course of recurrent, self-healing papulonecrotic or nodular skin lesions. Extracutaneous disease rarely develops.…”

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confidence: 99%

“…3 The prognosis of both conditions is usually excellent with a 5-year disease-specific survival of approximately 90% for C-ALCL and almost 100% for LyP. [2][3][4] However, about 10% of patients with primary cutaneous CD30…”

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confidence: 99%

No TP63 rearrangements in a selected group of primary cutaneous CD30+ lymphoproliferative disorders with aggressive clinical course

Schrader¹,

Chung²,

Jansen³

et al. 2016

Blood

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Primary cutaneous CD301 lymphoproliferative disorders (CD30 1 LPDs) are a disease spectrum including primary cutaneous anaplastic large cell lymphoma (C-ALCL) and lymphomatoid papulosis (LyP).1 C-ALCL presents as solitary, grouped, or, rarely, multifocal nodules and tumors that often ulcerate. Cutaneous relapses are common, but extracutaneous dissemination occurs in only 10% to 15% of patients and mainly involves regional lymph nodes. [2][3][4] LyP is characterized by a chronic course of recurrent, self-healing papulonecrotic or nodular skin lesions. Extracutaneous disease rarely develops.3 The prognosis of both conditions is usually excellent with a 5-year disease-specific survival of approximately 90% for C-ALCL and almost 100% for LyP. or TP63 rearrangement with 5-year survival rates of 17% and 42%, respectively.8-10

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Applicability and Prognostic Value of the New TNM Classification System in 135 Patients With Primary Cutaneous Anaplastic Large Cell Lymphoma

Cited by 97 publications

References 15 publications

ALK-positive anaplastic large cell lymphoma limited to the skin: clinical, histopathological and molecular analysis of 6 pediatric cases. A report from the ALCL99 study

ALK-positive anaplastic large cell lymphoma limited to the skin: clinical, histopathological and molecular analysis of 6 pediatric cases. A report from the ALCL99 study

SATB1 overexpression promotes malignant T-cell proliferation in cutaneous CD30+ lymphoproliferative disease by repressing p21

No TP63 rearrangements in a selected group of primary cutaneous CD30+ lymphoproliferative disorders with aggressive clinical course

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