Application and research progress of phase change materials in biomedical field

Ma, Kunlin; Zhang, Xuelai; Ji, Jun; Han, Lu; Ding, Xingjiang; Xie, Wenhao

doi:10.1039/d1bm00719j

Cited by 52 publications

(33 citation statements)

References 69 publications

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“… 49 Nevertheless, the mechanical strength is suitable or surpasses the needs of biomedical textiles and adds properties such as biocompatibility, lightweightness, safety, environmental impact, temperature regulation, and availability. 42 , 45 Other considerations should be studied; for instance, some biomedical textiles are designed to lose mechanical strength (for instance, by more than 90%, following 30 days after implantation), 62 for example, in sutures and wound-healing implants.…”

Section: Resultsmentioning

confidence: 99%

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Hollow Filaments Synthesized by Dry-Jet Wet Spinning of Cellulose Nanofibrils: Structural Properties and Thermoregulation with Phase-Change Infills

Reyes

Ajdary

Yazdani

et al. 2022

ACS Appl. Polym. Mater.

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We use dry-jet wet spinning in a coaxial configuration by extruding an aqueous colloidal suspension of oxidized nanocellulose (hydrogel shell) combined with airflow in the core. The coagulation of the hydrogel in a water bath results in hollow filaments (HF) that are drawn continuously at relatively high rates. Small-angle and wide-angle X-ray scattering (SAXS/WAXS) reveals the orientation and order of the cellulose sheath, depending on the applied shear flow and drying method (free-drying and drying under tension). The obtained dry HF show Young’s modulus and tensile strength of up to 9 GPa and 66 MPa, respectively. Two types of phase-change materials (PCM), polyethylene glycol (PEG) and paraffin (PA), are used as infills to enable filaments for energy regulation. An increased strain (9%) is observed in the PCM-filled filaments (HF-PEG and HF-PA). The filaments display similar thermal behavior (dynamic scanning calorimetry) compared to the neat infill, PEG, or paraffin, reaching a maximum latent heat capacity of 170 J·g –1 (48–55 °C) and 169 J·g –1 (52–54 °C), respectively. Overall, this study demonstrates the facile and scalable production of two-component core-shell filaments that combine structural integrity, heat storage, and thermoregulation properties.

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Section: Resultsmentioning

confidence: 99%

“… 43 , 44 The cellulose nanofiber shell component brings additional benefits of cost-effectiveness, biocompatibility, lightweightness, safety, and sustainability. 42 , 45 …”

Section: Introductionmentioning

confidence: 99%

Hollow Filaments Synthesized by Dry-Jet Wet Spinning of Cellulose Nanofibrils: Structural Properties and Thermoregulation with Phase-Change Infills

Reyes

Ajdary

Yazdani

et al. 2022

ACS Appl. Polym. Mater.

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“…Phase change materials can absorb much heat by melting in the phase change temperature range, and most phase change materials are solid-liquid phase changes. Taking advantage of these two characteristics, they have been widely used in biomedicine in drugs delivery systems ( Chen et al, 2018 ), biomarkers ( Wang et al, 2010 ), medical dressings ( Ma et al, 2021 ), and other aspects in recent years. The application of PCMs as drugs packaging materials in medical treatment can not only effectively solve the problem of drugs release but also may provide multifunctional features for tumor combined therapies.…”

Section: Pcmsmentioning

confidence: 99%

Applications of phase change materials in smart drug delivery for cancer treatment

Bao

et al. 2022

Front. Bioeng. Biotechnol.

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Phase change materials (PCMs) are materials that are stimulated by the external enthalpy change (temperature) to realize solid-liquid and liquid-solid phase transformation. Due to temperature sensitivity, friendly modification, and low toxicity, PCMs have been widely used in smart drug delivery. More often than not, the drug was encapsulated in a solid PCMs matrix, a thermally responsive material. After the trigger implementation, PCMs change into a solid-liquid phase, and the loading drug is released accordingly. Therefore, PCMs can achieve precise release control with different temperature adjustments, which is especially important for small molecular drugs with severe side effects. The combination of drug therapy and hyperthermia through PCMs can achieve more accurate and effective treatment of tumor target areas. This study briefly summarizes the latest developments on PCMs as smart gate-keepers for anti-tumor applications in light of PCMs becoming a research hot spot in the nanomedicine sector in recent years.

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“…Such materials can find widespread use especially in the building sector, textile and food industries and medicinal applications. [6][7][8][9][10][11][12][13] Fatty acids and some of their derivatives are important among PCMs because they have a suitable phase change temperature for thermal energy storage, low volume changes during phase change, less flammable, thermal, and chemical stability after phase change transformations, do not show toxic properties and are renewable substances [14] Esters of long chain fatty acids classified as organic PCMs, can absorb and store thermal energy as latent heat and then release this heat at certain phase transition temperature (Figure 1). [3,[15][16][17][18] Compared with free fatty acids, these compounds have some superior properties, such as being noncorrosive and having better latent heat properties.…”

Section: Introductionmentioning

confidence: 99%

“…Such materials can find widespread use especially in the building sector, textile and food industries and medicinal applications. [ 6–13 ]…”

Section: Introductionmentioning

confidence: 99%

An Ionic Liquid Promoted Clean and Direct Conversion of Triglycerides into Bio‐Based Thermal Energy Storage Materials

Yıldırım

2022

Euro J Lipid Sci & Tech

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In the present study, triglycerides are subjected to an ionic liquid (IL) catalyzed and solventless transesterification reaction with a series of fatty alcohols in a 1:3 ratio, respectively. In order to prepare the corresponding wax esters, triglycerides trilaurin, trimyristin, and tristearin are treated with fatty alcohols such as lauryl, myristyl, and stearyl alcohol via 1,3‐disulfonic acid imidazolium chloride catalyzed transesterification reaction under environmentally friendly conditions. The optimum duration of the transesterification reaction is determined by proton nuclear magnetic resonance spectroscopy and the progress of the reaction can also be easily followed by thin layer chromatography. According to these studies, the reaction takes about 2 h to complete and the corresponding wax esters are obtained successfully by recrystallization from suitable solvent mixture without tedious work‐up in good to excellent yields (86–100%). Practical Applications: With this sustainable method, a homologous series of wax esters can be successfully synthesized as bio‐based thermal energy storage materials. The prominent aspect of this solventless method is that it allows the preparation of wax esters directly from triglycerides via an ionic liquid catalyzed process both in laboratory and industrial scale.

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Application and research progress of phase change materials in biomedical field

Abstract: Phase change materials (PCMs) are widely used in solar energy utilization, industrial waste heat recovery and building temperature regulation. However, there are few studies on the application of PCMs in...

Cited by 52 publications

References 69 publications

Hollow Filaments Synthesized by Dry-Jet Wet Spinning of Cellulose Nanofibrils: Structural Properties and Thermoregulation with Phase-Change Infills

Hollow Filaments Synthesized by Dry-Jet Wet Spinning of Cellulose Nanofibrils: Structural Properties and Thermoregulation with Phase-Change Infills

Applications of phase change materials in smart drug delivery for cancer treatment

An Ionic Liquid Promoted Clean and Direct Conversion of Triglycerides into Bio‐Based Thermal Energy Storage Materials

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