The traditional combination filter method in the practical process is often two layers of composite filtering de-noising for the image containing the gaussian mixture noise and pulse noise. This paper proposes a three filter combination algorithm based on the two layers filters, To the Gaussian and pulse mixed noise of the remote sensing image, we use wavelet threshold de-nosing and adaptive median filter de-nosing, and then using the third layer adaptive Wiener filtering de-noising to remove the residual noise. Through theoretical analysis and practical application, the de-nosing results of this method is obvious in processing mixed noise of remote sensing image, this is a practical method of combination filtering de-noising, it can be widely used in the field of image processing.