Application of 2 Different Hemostatic Procedures During Microsurgical Median Nerve Reconstruction in the Rat Does Not Hinder Axonal Regeneration

Sinis, Nektarios; Manoli, Theodora; Schiefer, Jennifer Lynn; Werdin, Frank; Jaminet, Patrick; Kraus, Armin; Fornaro, Michele; Raimondo, Stefania; Geuna, Stefano; Schaller, Hans-Eberhard

doi:10.1227/neu.0b013e3182127bc4

Cited by 2 publications

(1 citation statement)

References 18 publications

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“… Six weeks ? Sinis et al, 2009 [ 93 ] Administration of Deferoxamine Wistar 48 Nerve transection / / Weekly 4 weeks 12 weeks Sinis et al, 2011 [ 94 ] Hemostatic procedures during nerve reconstruction Wistar 36 Nerve transection / / Weekly 4 weeks 12 weeks Stößel et al, 2017 [ 22 ] Reflex-based grasping, skilled forelimb reaching and electrodiagnostic evaluation in comparison Lewis 16 Nerve transection 7 mm 7 mm Every 4 weeks 5 weeks 12 weeks Werdin et al, 2009 [ 30 ] Electrophysical testing Wistar 54 Nerve transection 20 mm 20 mm Weekly after 4 weeks postoperatively for 20 weeks Neurorrhaphy: 5 weeks Autograft: 12 weeks 16 weeks …”

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confidence: 99%

The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury

et al. 2022

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The rat median nerve model is a well-established and frequently used model for peripheral nerve injury and repair. The grasping test is the gold-standard to evaluate functional recovery in this model. However, no comprehensive review exists to summarize the course of functional recovery in regard to the lesion type. According to PRISMA-guidelines, research was performed, including the databases PubMed and Web of Science. Groups were: (1) crush injury, (2) transection with end-to-end or with (3) end-to-side coaptation and (4) isogenic or acellular allogenic grafting. Total and respective number, as well as rat strain, type of nerve defect, length of isogenic or acellular allogenic allografts, time at first signs of motor recovery (FSR) and maximal recovery grasping strength (MRGS), were evaluated. In total, 47 articles met the inclusion criteria. Group I showed earliest signs of motor recovery. Slow recovery was observable in group III and in graft length above 25 mm. Isografts recovered faster compared to other grafts. The onset and course of recovery is heavily dependent from the type of nerve injury. The grasping test should be used complementary in addition to other volitional and non-volitional tests. Repetitive examinations should be planned carefully to optimize assessment of valid and reliable data.

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Section: Table A1mentioning

confidence: 99%

The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury

et al. 2022

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The Median Nerve Injury Model in Pre-clinical Research – A Critical Review on Benefits and Limitations

Ronchi

Morano

Fregnan

et al. 2019

Front. Cell. Neurosci.

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The successful introduction of innovative treatment strategies into clinical practise strongly depends on the availability of effective experimental models and their reliable pre-clinical assessment. Considering pre-clinical research for peripheral nerve repair and reconstruction, the far most used nerve regeneration model in the last decades is the sciatic nerve injury and repair model. More recently, the use of the median nerve injury and repair model has gained increasing attention due to some significant advantages it provides compared to sciatic nerve injury. Outstanding advantages are the availability of reliable behavioural tests for assessing posttraumatic voluntary motor recovery and a much lower impact on the animal wellbeing. In this article, the potential application of the median nerve injury and repair model in pre-clinical research is reviewed. In addition, we provide a synthetic overview of a variety of methods that can be applied in this model for nerve regeneration assessment. This article is aimed at helping researchers in adequately adopting this in vivo model for pre-clinical evaluation of peripheral nerve reconstruction as well as for interpreting the results in a translational perspective.

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Application of 2 Different Hemostatic Procedures During Microsurgical Median Nerve Reconstruction in the Rat Does Not Hinder Axonal Regeneration

Cited by 2 publications

References 18 publications

The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury

The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury

The Median Nerve Injury Model in Pre-clinical Research – A Critical Review on Benefits and Limitations

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