Hydrogeological conditions largely depend on the permeability of the geological environment. In areas with complex geological and tectonic conditions, the detection of hydraulic heterogeneity of the rocks and determination of groundwater-rich zones is a challenge for hydrogeological practice. The aim of the study is to analyze the geological and tectonic prerequisites for hydraulic heterogeneity of the sediments for the Gotse Delchev valley (Southwestern Bulgaria), which predetermine the degree of their water productivity. In order to obtain more precise data for specific sites, a geophysical survey was conducted. The Self-Potential method was chosen, which is one of the most commonly used techniques for applications for hydrogeological purposes. The results of the geophysical survey carried out in selected sites allowed to locate groundwater-rich zones, to establish the depth of occurrence of hard low permeable rocks, as well as to confirm the presence of faults.