Application of Advanced Solid‐State NMR Techniques to the Characterization of Nanomaterials: A Focus on Interfaces and Structure

Baccile, Niki

doi:10.1002/9783527630530.ch6

Cited by 4 publications

(2 citation statements)

References 186 publications

(305 reference statements)

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“…Contrary to other techniques, SS NMR can be applied to any solid physical state (both crystalline and amorphous) and materials of different complexity, from pure APIs or excipients to solid dispersions (including commercial preparations) [ 165 ]. Moreover, the development of NMR methodology and the use of new experiments, especially fast magic angle spinning (MAS) [ 170 , 171 , 172 , 173 ], dynamical nuclear polarization (DNP), and surface-enhanced NMR spectroscopy (SENS) [ 174 , 175 , 176 ], makes the SS NMR the premier method in the study of mesoporous materials, drugs confined in nanocarriers and API-MSN interactions [ 170 , 177 , 178 ].…”

Section: Analytical Techniquesmentioning

confidence: 99%

Mesoporous Silica Particles as Drug Delivery Systems—The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes

et al. 2021

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Conventional administration of drugs is limited by poor water solubility, low permeability, and mediocre targeting. Safe and effective delivery of drugs and therapeutic agents remains a challenge, especially for complex therapies, such as cancer treatment, pain management, heart failure medication, among several others. Thus, delivery systems designed to improve the pharmacokinetics of loaded molecules, and allowing controlled release and target specific delivery, have received considerable attention in recent years. The last two decades have seen a growing interest among scientists and the pharmaceutical industry in mesoporous silica nanoparticles (MSNs) as drug delivery systems (DDS). This interest is due to the unique physicochemical properties, including high loading capacity, excellent biocompatibility, and easy functionalization. In this review, we discuss the current state of the art related to the preparation of drug-loaded MSNs and their analysis, focusing on the newest advancements, and highlighting the advantages and disadvantages of different methods. Finally, we provide a concise outlook for the remaining challenges in the field.

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Section: Analytical Techniquesmentioning

confidence: 99%

Mesoporous Silica Particles as Drug Delivery Systems—The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes

et al. 2021

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“…117 The development of fast magic angle spinning (MAS) [118][119][120][121] and single-pulse experiment (SPE), makes the SS NMR the main method to study mesoporous materials, particularly drugs confined in MPS, drug-coformer interaction within MPS, and API-MPS interactions. 122,123 The crosspolarization/magic angle spinning experiments have been conducted by Bi et al using a double-tuned crosspolarization/magic angle spinning probe to justify the formation of coamorphous systems of IBU-NA loaded MPS. The spectra of the NCA system show a 0.4-0.5 ppm downfield shift of the methyl resonances of IBU and a 0.6 ppm upfield shift of the carboxyl resonance when compared to the spectrum of physical mixture of IBU and NA-loaded MPS.…”

Section: Solid-state Nmr (Ss Nmr)mentioning

confidence: 99%

Drug-Coformer Loaded-Mesoporous Silica Nanoparticles: A Review of the Preparation, Characterization, and Mechanism of Drug Release

Budiman,

Wardhana,

Ainurofiq

et al. 2024

IJN

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Drug-coformer systems, such as coamorphous and cocrystal, are gaining recognition as highly effective strategies for enhancing the stability, solubility, and dissolution of drugs. These systems depend on the interactions between drug and coformer to prevent the conversion of amorphous drugs into the crystalline form and improve the solubility. Furthermore, mesoporous silica (MPS) is also a promising carrier commonly used for stabilization, leading to solubility improvement of poorly water-soluble drugs. The surface interaction of drug-MPS and the nanoconfinement effect prevent amorphous drugs from crystallizing. A novel method has been developed recently, which entails the loading of drug-coformer into MPS to improve the solubility, dissolution, and physical stability of the amorphous drug. This method uses the synergistic effects of drug-coformer interactions and the nanoconfinement effect within MPS. Several studies have reported successful incorporation of drug-coformer into MPS, indicating the potential for significant improvement in dissolution characteristics and physical stability of the drug. Therefore, this study aimed to discuss the preparation and characterization of drug-coformer within MPS, particularly the interaction in the nanoconfinement, as well as the impact on drug release and physical stability.

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Tailoring B-doped silicon nanocrystal surface chemistry via phosphorus pentachloride – mediated surface alkoxylation

et al. 2021

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Application of Advanced Solid‐State NMR Techniques to the Characterization of Nanomaterials: A Focus on Interfaces and Structure

Cited by 4 publications

References 186 publications

Mesoporous Silica Particles as Drug Delivery Systems—The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes

Mesoporous Silica Particles as Drug Delivery Systems—The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes

Drug-Coformer Loaded-Mesoporous Silica Nanoparticles: A Review of the Preparation, Characterization, and Mechanism of Drug Release

Tailoring B-doped silicon nanocrystal surface chemistry via phosphorus pentachloride – mediated surface alkoxylation

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