Application of Anodic Stripping Voltammetry for Zinc, Copper, and Cadmium Quantification in the Aqueous Humor: Implications of Pseudoexfoliation Syndrome

Panteli, Vassiliki S.; Kanellopoulou, Dimitra G.; Gartaganis, Sotirios P.; Koutsoukos, Petros G.

doi:10.1007/s12011-009-8380-3

Cited by 12 publications

(8 citation statements)

References 27 publications

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“…2006). Alternatively, zink, copper and cadmium could have been present in the aqueous of cataract patients, as shown by anodic stripping voltametry (Panteli et al. 2009).…”

Section: Discussionmentioning

confidence: 99%

Spectroscopic study of explanted opacified hydrophilic acrylic intraocular lenses

Fodor¹,

Petrovski²,

Moe³

et al. 2011

Acta Ophthalmologica

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. Purpose: To report a detailed spectroscopic analysis of explanted hydrophilic acrylic intraocular lenses (IOLs) that were removed because of postoperative opacification of the lens optic. Methods: Thirteen Hydroview H60M (Bausch & Lomb Surgical) IOLs were explanted from 13 different patients on average 56 months after phacoemulsification and IOL implantation. All patients had decreased visual acuity because of a fine granularity of the optical surface of the IOLs. The surface was investigated by gross, microscopic, histochemical and scanning electron microscopic analysis, and the elemental composition of the opacified IOLs was determined by X‐ray fluorescence spectroscopy (XRF). The spectrograms were compared to three different originally packed and never‐implanted hydrophilic acrylic IOLs. Results: Light and scanning electron microscopy of the optical surface of explanted IOLs revealed multiple fine granular deposits varying in size and shape that were positive for alizarin red. XRF confirmed that the explanted IOLs contained not only the previously reported calcium and phosphorous (calcium apatite), chlorine, silicone, sodium, aluminum and magnesium but also iron, sulfur, potassium as well as lesser amounts of iodine, zinc, strontium and yttrium. Conclusion: This is the first spectroscopic analysis determining the content of more than 10 elements of explanted and originally packed never‐implanted hydrophilic acrylic IOLs. The possible origin of the different elements obtained from the spectrograms and their implications are discussed.

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“…2006). Alternatively, zink, copper and cadmium could have been present in the aqueous of cataract patients, as shown by anodic stripping voltametry (Panteli et al. 2009).…”

Section: Discussionmentioning

confidence: 99%

Spectroscopic study of explanted opacified hydrophilic acrylic intraocular lenses

Fodor¹,

Petrovski²,

Moe³

et al. 2011

Acta Ophthalmologica

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“…A wavelet transform was previously used to extract the most relevant information from voltammograms [ 51 ]. We used individual ions peak heights as the ANN input data, because Cd(II) and Zn(II) ions in samples tended to affect the peak heights of each other instead of overlapping (peaks of Cd(II), Cu(II) and Pb(II) and Zn(II) are well separated) [ 41 ]. The neural network reliability was tested using 22 mineralized blood plasma samples with random heavy metal concentrations (0.0–6 μg·mL −1 ) and 20 randomly selected heavy metal mixtures (0.01–8 μg·mL −1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The choice of the carbon tip electrode modified with mercury film as a working electrode, signal stability and reproducibility of known metal solution levels are reported. Moreover, artificial neural networks software-based techniques developed to analyse the complex data sets were also used in this study [ 37 – 40 ], because it was found that the presence of copper and zinc in samples may lead to the formation of intermetallic compounds on the mercury film and this affects analysis of both elements [ 41 ]. The correct zinc concentration in the presence of copper and vice versa can be, however, determined by ANN processing [ 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Automatic Electrochemical Detection of Zinc, Cadmium, Copper and Lead Ions in Environmental Samples Using a Thin-Film Mercury Electrode and an Artificial Neural Network

Kudr

Nguyen

Gumulec

et al. 2014

Sensors

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In this study a device for automatic electrochemical analysis was designed. A three electrodes detection system was attached to a positioning device, which enabled us to move the electrode system from one well to another of a microtitre plate. Disposable carbon tip electrodes were used for Cd(II), Cu(II) and Pb(II) ion quantification, while Zn(II) did not give signal in this electrode configuration. In order to detect all mentioned heavy metals simultaneously, thin-film mercury electrodes (TFME) were fabricated by electrodeposition of mercury on the surface of carbon tips. In comparison with bare electrodes the TMFEs had lower detection limits and better sensitivity. In addition to pure aqueous heavy metal solutions, the assay was also performed on mineralized rock samples, artificial blood plasma samples and samples of chicken embryo organs treated with cadmium. An artificial neural network was created to evaluate the concentrations of the mentioned heavy metals correctly in mixture samples and an excellent fit was observed (R2 = 0.9933).

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“…Cadmium accumulates with age in the retinal pigment epithelium, 36 and findings of studies 14,37,38 have led to the hypothesis that it is a possible contributor to age-related macular degeneration. While the association between body cadmium level and glaucoma has not been well investigated, one study 39 showed that it was detected in a small number of aqueous humor samples from individuals with glaucoma. Our study has some limitations.…”

Section: Discussionmentioning

confidence: 99%

Association Between Body Levels of Trace Metals and Glaucoma Prevalence

2015

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laucoma is an optic neuropathy associated with retinal ganglion cell loss and structural alteration of the optic nerve head. It is the leading cause of irreversible blindness worldwide 1 and a growing public health concern because of an aging global population. 2 The etiology of glaucoma is multifactorial, with validated risk factors that include greater intraocular pressure (IOP), older age, and a positive family history. 3 Other possible concomitant factors include high glutamate levels, 4 alterations in nitric oxide metabolism, 5 and vascular changes. 6 Findings from a prior study 7 suggest that oxidative stress and free radical accumulation may harm the trabecular meshwork, resulting in an increase in IOP. Such oxidative stress may also be harmful to retinal ganglion cells, with resultant cell death that leads to optic nerve damage characteristic of glaucoma. 8 Trace metals demonstrated to be essential for normal cellular function of the human body include iron, copper, magnesium, and manganese. These elements serve as activators or cofactors for many transporters, transcription factors, and enzymes. Disruption of essential element metabolism can result in severe dysfunction and diseases in many organ systems. Abnormal essential element levels or exposure to toxic trace metals (eg, lead, mercury, and arsenic) has been postulated to have a role in neurodegenerative diseases, 9 coronary IMPORTANCE Abnormal body levels of essential elements and exposure to toxic trace metals have been postulated to contribute to the pathogenesis of diseases affecting many organ systems, including the eye. OBJECTIVE To investigate associations between body levels of trace metals and the prevalence of glaucoma in a cross-sectional population-based study. DESIGN, SETTING, AND PARTICIPANTS Blood or urine metallic element levels and information pertaining to ocular disease were available for 2680 individuals 19 years and older participating in the fourth Korea National Health and Nutrition Examination Survey between January 1, 2008, and December 31, 2009, the second and the third years of the survey (2007-2009). Glaucoma diagnosis was based on criteria established by the International Society of Geographic and Epidemiologic Ophthalmology. Demographic, comorbidity, and health-related behavior information was obtained via interview. Multivariable logistic regression analyses were performed to determine associations between blood and urine trace element levels and the odds of glaucoma diagnosis. All analyses were performed between September 2014 and December 2014. MAIN OUTCOME AND MEASURE The presence or absence of glaucoma. RESULTS After adjustment for potential confounders, blood manganese level was negatively associated with the odds of glaucoma diagnosis (odds ratio [OR], 0.44; 95% CI, 0.21-0.92). Blood mercury level was positively associated with glaucoma prevalence (OR, 1.01; 95% CI, 1.00-1.03). No definitive association was identified between blood cadmium or lead levels or urine arsenic level and a diagnosis of glaucoma. CONCLUS...

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Application of Anodic Stripping Voltammetry for Zinc, Copper, and Cadmium Quantification in the Aqueous Humor: Implications of Pseudoexfoliation Syndrome

Cited by 12 publications

References 27 publications

Spectroscopic study of explanted opacified hydrophilic acrylic intraocular lenses

Spectroscopic study of explanted opacified hydrophilic acrylic intraocular lenses

Simultaneous Automatic Electrochemical Detection of Zinc, Cadmium, Copper and Lead Ions in Environmental Samples Using a Thin-Film Mercury Electrode and an Artificial Neural Network

Association Between Body Levels of Trace Metals and Glaucoma Prevalence

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