Background: The IoT and big data are newer technologies that can provide substantial support for healthcare systems, helping them overcome their shortcomings. The aim of this paper was to analyze the relevant literature descriptively, thematically, and chronologically from an interdisciplinary perspective in a holistic way to identify the most prolific research entities and themes. Methods: Synthetic knowledge synthesis qualitatively and quantitatively analyzes the production of literature through a combination of descriptive bibliometrics, bibliometric mapping, and content analysis. For this analysis, the Scopus bibliometric database was used. Results: In the Scopus database, 2272 publications were found; these were published between 1985 and 10 June 2024. The first article in this field was published in 1985. Until 2012, the production of such literature was steadily increasing; after that, exponential growth began, peaking in 2023. The most productive countries were the United States, India, China, the United Kingdom, South Korea, Germany, and Italy. The content analysis resulted in eight themes (four from the perspective of computer science and four from the perspective of medicine) and 21 thematic concepts (8 from the perspective of computer science and 13 from the perspective of medicine). Conclusions: The results show that the IoT and big data have become key technologies employed in preventive healthcare. The study outcomes might represent a starting point for the further development of research that combines the multidisciplinary aspects of healthcare.