Application of bromate-bromide mixture as a green brominating agent for the spectrophotometric determination of atenolol in pharmaceuticals

Abstract

Two highly sensitive spectrophotometric methods are proposed for the quantification of atenolol (ATN) in pure drug as well as in pharmaceutical formulations. The methods are based on the bromination reaction of ATN with a known excess of bromate-bromide mixture in acid medium followed by the determination of unreacted bromine. The residual bromine is determined by its reaction with excess iodide and the liberated iodine (I3□) is either measured at 360 nm (method A) or reacted with starch followed by the measurement of the starch-iodine chromogen at 570 nm (method B). Under the optimum conditions, ATN could be assayed in the concentration ranges of 0.5-9.0 and 0.3-6.0μg mL-1 for method A and method B, respectively, with corresponding molar absorptivity values of 2.36×104 and 2.89×104 L/mol.cm. Sandell’s sensitivity values are found to be 0.0113 and 0.0092 μg/cm2 for method A and method B, respectively. The proposed methods were successfully applied to the analysis of different commercial brands of pharmaceutical formulations and the results obtained by the proposed methods were in good agreement with those obtained using the reference method. The reliability of the methods was further ascertained by recovery studies using standard- addition method

Review on different analytical techniques for analysis of atenolol alone or in combination with other antihypertensive drugs in different matrices

“…• Application of bromate-bromide mixture as a green brominating agent: The methods were based on the bromination reaction of atenolol with a known excess of the bromate-bromide mixture in acid medium followed by the determination of unreacted bromine. The residual bromine was determined by its reaction with excess iodide and the liberated iodine was either measured at 360 nm (method A) or reacted with starch followed by the measurement of the starch-iodine chromogen at 570 nm (method B) [38].…”

Spectrophotometric Determination of Atenolol Using Indigo Carmine Dye

“…It is necessary to develop analytical methods for the determination of drug in commercial dosage forms because of the great use of drug. Several analytical methods have been reported which are based on the bromination reaction of ATN with a known excess of bromate-bromide mixture in acid medium [5,6] or based on the oxidation of the ATN by a known excess of cerric (IV) in acid medium [7], or titration of the drug in glacial acetic acid with acetous perchloric acid to the visual end point using crystal violet as indicator [8]. UV spectrophotometric methods with sensitive titrimetric used for determination of ATN in tablet formulations [9].…”