2015
DOI: 10.1016/j.aquatox.2015.09.004
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Application of cellular biosensors for detection of atypical toxic bioactivity in microcystin-containing cyanobacterial extracts

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Cited by 12 publications
(5 citation statements)
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“…Further, new cyanotoxins are continuously being discovered and this work should continue to remain at the forefront of protecting human and ecological health. 99,100 For example, Mankiewics-Boczek et al (2015) recently found that cellular biosensors detected toxic bioactivity in cyanobacterial extracts that exceeded toxicity levels for MCs; including effects on lipopolysaccharides and cellular wall components. 100 Finally, the toxicity of degradation products of MCs should be explored.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Further, new cyanotoxins are continuously being discovered and this work should continue to remain at the forefront of protecting human and ecological health. 99,100 For example, Mankiewics-Boczek et al (2015) recently found that cellular biosensors detected toxic bioactivity in cyanobacterial extracts that exceeded toxicity levels for MCs; including effects on lipopolysaccharides and cellular wall components. 100 Finally, the toxicity of degradation products of MCs should be explored.…”
Section: Discussionmentioning
confidence: 99%
“…99,100 For example, Mankiewics-Boczek et al (2015) recently found that cellular biosensors detected toxic bioactivity in cyanobacterial extracts that exceeded toxicity levels for MCs; including effects on lipopolysaccharides and cellular wall components. 100 Finally, the toxicity of degradation products of MCs should be explored. 101,102…”
Section: Discussionmentioning
confidence: 99%
“…Commercially available adenocarcinoma cell lines were used for the assessment of the effect of the compounds on the activity of transcription factor AP-1 (Luciferase Reporter Stable HeLa cell line, 350-SL-0019-NP; Signosis, Inc., Santa Clara, CA, USA). A stable ovarian cancer reporter cell line NF-κB (SkoV3-Nf-κB) from the Regulation Laboratory IBM PAN, Poland, derived as previously described [68,69], was used for the assessment of NF-κB promoter activity. The cells were seeded into 96-well plates in the density of 1 × 10 4 cell/well and maintained in culture medium for 24 h to allow attachment to the plate surface.…”
Section: Reporter Gene Cell Lines and Ap-1 And Nf-κb Activity Assaysmentioning
confidence: 99%
“…Microcystins, mainly produced by freshwater blue-green algae, are the most common algal toxins. They have the highest occurrence frequency in cyanobacteria blooms and have already resulted in very serious impacts on people [9,10]. Among microcystins, microcystin-LR (MC-LR) has been shown to be one of the most toxic and harmful algal toxins [11].…”
Section: Removal Of Chlorophyll-a and Microcystin-lrmentioning
confidence: 99%