Application of Compound Ketamine and Pentobarbital Sodium in Orthopedic Surgery on Mice and Its Anesthesia Effect

Abstract

To compare the anesthesia effect of compound ketamine and pentobarbital sodium in orthopedic surgery, 30 specific pathogen free C57BL/6J male mice were included and randomly enrolled into group A (compound ketamine group) and group B (pentobarbital sodium group). The changes of respiratory frequency, heart rate, body temperature, blood oxygen saturation, anesthesia duration, and anesthesia depth among mice in the two groups were compared. It was demonstrated that respiratory frequency declined in the two groups. Heart rate showed no apparent changes as anesthesia was continued. Heart rate was high in group A at 50 min while it was low in group B at 90 min. Body temperature among mice in the two groups generally declined. After 90 min, it dramatically declined in group A. Body temperature was the lowest in group B at 90 min. Blood oxygen saturation generally raised in the two groups. As to anesthesia duration, induction and anesthesia periods were relatively longer in group B. The score for anesthesia depth of group B remained above 3 points 20 min after rectification disappeared and anesthesia duration of group B was notably longer. The research findings revealed that compound ketamine and pentobarbital sodium showed excellent anesthesia effects and physiological indicators. The latter one was characterized by long anesthesia duration, low safety, and high fatality.