Application of comprehensive two-dimensional gas chromatography to drugs analysis in doping control

Kueh, A.J.; Marriott, Philip J.; Wynne, Paul; Vine, John

doi:10.1016/s0021-9673(02)01998-2

Cited by 63 publications

(35 citation statements)

References 45 publications

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“…If the MS recovery does not fall within the method acceptance criteria, it may be an indication of sample matrix interferences. However, the matrix interference may only be present in the sample used for the MS. Several examples are given in the literature concerning the use of spiked samples as control samples in pesticide analysis [9] or in pharmaceutical analysis [10].…”

Section: Matrix Spike Samplesmentioning

confidence: 99%

Quality assurance considerations in chemical analysis

Rauf

Hanan

2009

Quality Assurance Journal

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SummaryQuality Assurance (QA) for an analytical laboratory is an essential tool to ensure good comparability of data. In order to achieve this purpose, processes are monitored and performance problems are systematically solved. A variety of texts exists such as Good Laboratory Practice and the Quality Assurance Systems ISO 9001 and ISO 17025. However, these international standards provide only general rules to install and maintain a quality system. It remains the responsibility of the laboratory to define appropriate procedures to ensure that proper quality is achieved. Adherence to QA guidelines, participation in inter-laboratory studies, use of reference materials (RM) and certified reference materials (CRM) are all means of achieving good data quality for determinations.

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Section: Matrix Spike Samplesmentioning

confidence: 99%

Quality assurance considerations in chemical analysis

Rauf

Hanan

2009

Quality Assurance Journal

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“…In particular, Farag et al [76] have reported the identification of 28 previously uncharacterized volatiles (the majority of which were branchedchain alcohols) from two strains of rhizobacterial Bacilli. Recent advances, such as fast GC [80] and GC×GC [81,82] (both reviewed in [83] coupled with MS, have significantly improved the throughput and coverage, respectively, of sample analyses. Mondello et al recently compared conventional GC and fast GC in fatty acid profiling analyses of fats and oils [84].…”

Section: Metabolomics Technologiesmentioning

confidence: 99%

Future of Liquid Chromatography–Mass Spectrometry in Metabolic Profiling and Metabolomic Studies for Biomarker Discovery

et al. 2007

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SUMMARYThe future utility of liquid chromatography-mass spectrometry (LC-MS) in metabolic profiling and metabolomic studies for biomarker discover will be discussed, beginning with a brief description of the evolution of metabolomics and the utilization of the three most popular analytical platforms in such studies: NMR, GC-MS, and LC-MS. Emphasis is placed on recent developments in highefficiency LC separations, sensitive electrospray ionization approaches, and the benefits to incorporating both in LC-MS-based approaches. The advantages and disadvantages of various quantitative approaches are reviewed, followed by the current LC-MS-based tools available for candidate biomarker characterization and identification. Finally, a brief prediction on the future path of LC-MS-based methods in metabolic profiling and metabolomic studies is given.

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“…In this paper, the molecular structure and electronic properties of 2, 18,19,20,20.01,8.03,7.09,14.024,11,13,17(31),18,24,26, were calculated by the B3LYP density functional model using 6-31G, 6-311G, 6-311++G and 6-311++G(d,p) basis sets. B3LYP calculation results indicated some selected bond length and bond angle values for this molecule.…”

Section: Introductionmentioning

confidence: 99%

“…Pyrrole constitutes an important class of five-membered ring heterocycles with remarkable biological activities [21,22], such as antitumour [23], analgesic [24,25], antidepressant [26], antihistaminic [27], anti-inflammatory [28] and anti-parkinson [29,30]. Furthermore, they are useful structures in the synthesis of natural products and heterocycles and are also widely used in material science.…”

Section: Introductionmentioning

confidence: 99%

Computational Studies and Energies for the Dioxa-Pentaazaheptacyclo-Hentriaconta-Octaen-One through Density Functional Theory and Natural Bond Orbital

Shahbazi¹,

Ghammamy²

2014

UCMS

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Abstract:In this paper, the molecular structure and electronic properties of 2, 18,19,20,20.01,8.03,7.09,14.024,11,13,17(31),18,24,26, were calculated by the B3LYP density functional model using 6-31G, 6-311G, 6-311++G and 6-311++G(d,p) basis sets. B3LYP calculation results indicated some selected bond length and bond angle values for this molecule. The optimized geometries and frequencies of the stationary point and the minimum-energy of this structure were recognized. The obtained results were compared with the corresponding experimental data. Trustworthiness of this results is confirmed by good agreement with the experimental analyzes of this structure. The results obtained by different basis sets were compared and the necessity of correlation methods for studying these systems is discussed.

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Application of comprehensive two-dimensional gas chromatography to drugs analysis in doping control

Cited by 63 publications

References 45 publications

Quality assurance considerations in chemical analysis

Quality assurance considerations in chemical analysis

Future of Liquid Chromatography–Mass Spectrometry in Metabolic Profiling and Metabolomic Studies for Biomarker Discovery

Computational Studies and Energies for the Dioxa-Pentaazaheptacyclo-Hentriaconta-Octaen-One through Density Functional Theory and Natural Bond Orbital

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