Application of dispersive liquid–liquid microextraction and CE with UV detection for the chiral separation and determination of the multiple illicit drugs on forensic samples

Meng, Liang; Wang, Bin; Luo, Feng; Shen, Guijun; Wang, Zhengqiao; Guo, Mengping

doi:10.1016/j.forsciint.2010.12.003

Cited by 53 publications

(34 citation statements)

References 30 publications

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“…tempo de extração muito curto, ou seja, a extração é tempo-independente (REZAEE et al, 2006;EBRAHIMZADEH et al, 2009;REZAEE et al, 2010;MENG et al, 2011 (REZAEE et al, 2006;OJEDA e ROJAS, 2009;REZAEE et al, 2010;MENG et al, 2011).…”

Section: Dllmeunclassified

“…Na DLLME, os fatores que afetam a eficiência da extração são: i) tipo de solvente extrator, ii) tipo de solvente dispersor, iii) volume do solvente extrator, iv) volume do solvente dispersor, v) tempo de extração, vi) agitação da amostra e vii) pH (REZAEE et al, 2006;OJEDA e ROJAS, 2009;REZAEE et al, 2010;MENG et al, 2011;ZGOLA-GRZESKOWIAK e GRZESKOWIAK, 2011). Dessa forma, esses fatores devem ser otimizados durante o desenvolvimento da metodologia analítica.…”

Section: Dllmeunclassified

“…Com relação aos solventes empregados, o solvente extrator deve possui algumas características, como: ser imiscível em água, possuir densidade maior que a água, ser facilmente volatilizável, ter capacidade de extração do composto de interesse e uma boa compatibilidade com o sistema cromatográfico (REZAEE et al, 2006;OJEDA e ROJAS, 2009;REZAEE et al, 2010;MENG et al, 2011;ZGOLA-GRZESKOWIAK e GRZESKOWIAK, 2011). Ele representa o parâmetro mais importante neste tipo de extração (REZAEE et al, 2006;OJEDA e ROJAS, 2009;REZAEE et al, 2010;MENG et al, 2011).…”

Section: Otimização Do Solvente Extratorunclassified

“…Ele representa o parâmetro mais importante neste tipo de extração (REZAEE et al, 2006;OJEDA e ROJAS, 2009;REZAEE et al, 2010;MENG et al, 2011). …”

Section: Otimização Do Solvente Extratorunclassified

“…Com relação ao solvente dispersor, o mesmo deve possuir uma boa miscibilidade tanto na fase extratora, como na fase aquosa e também ser facilmente volatilizável (REZAEE et al, 2006;OJEDA e ROJAS, 2009;REZAEE et al, 2010;MENG et al, 2011;ZGOLA-GRZESKOWIAK e GRZESKOWIAK, 2011). Esse solvente é responsável por permitir a formação do ponto nuvem e pela sedimentação da fase extratora (REZAEE et al, 2009 Concentração da fase sedimentada, C0: Concentração dos analitos na fase aquosa), sendo que, à medida que o volume deste solvente aumenta, o volume da fase sedimentada após a centrifugação também aumenta, diminuindo a concentração do analito na fase sedimentada e portanto, ocasionando uma diminuição do FE (REZAEE et al, 2006;REZAEE et al, 2010;MENG et al, 2011 (REZAEE et al, 2010).…”

Section: Otimização Do Solvente Dispersorunclassified

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Metta¹

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Section: Dllmeunclassified

Section: Otimização Do Solvente Extratorunclassified

“…Ele representa o parâmetro mais importante neste tipo de extração (REZAEE et al, 2006;OJEDA e ROJAS, 2009;REZAEE et al, 2010;MENG et al, 2011). …”

Section: Otimização Do Solvente Extratorunclassified

Section: Otimização Do Solvente Dispersorunclassified

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Metta¹

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Chiral Separations by Capillary Electrophoresis

Sánchez-López

Castro-Puyana

Marina

et al. 2015

Analytical Separation Science

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The enantiomeric separation of chiral compounds is nowadays a promising topic in analytical sciences. CE is considered as a well‐established tool to perform chiral separations of a wide range of analytes in different research fields such as pharmaceutical, food and chemical industries, and clinical and environmental laboratories. Due to its numerous advantages such as high efficiency, simplicity, and low consumption of reagents, chiral selectors, and samples, CE plays an important role in the separation of enantiomers. Advantages and limitations of the different CE modes are displayed in the present chapter, discussing their possibilities and the actual trends. Hyphenation with MS detection is also discussed, highlighting the potential of this coupling as well as its weaknesses and, the most commonly used strategies to minimize its drawbacks. Most recent and relevant applications of chiral CE are summarized and illustrated with tables including the analysis of pharmaceutical, biological, and environmental samples, food and beverages, and agrochemicals. Finally, concluding remarks and future trends are also included describing the actual state of the art and challenges of chiral CE techniques.

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Recent advances in the application of CE to forensic sciences, an update over years 2009–2011

2011

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The present article reviews and comments the applications of capillary electrophoresis in the different areas of forensic sciences covering the time from the second half of 2009 until the first part of 2011, being the latest update of previous reviews covering the years from 2001 to 2009. Numerous articles reporting applications of capillary electrophoresis to analytical problems of potential interest for the forensic researchers and scientists can be found in the most qualified journals of analytical chemistry, analytical biochemistry, pharmacology, toxicology, laboratory medicine, human genetics, etc. However, the present review has been focused on discussing only the most relevant examples of analytical applications of capillary electrophoretic and electrokinetic techniques published in the following fields: (i) illicit and abused drugs, (ii) ions and small molecules of forensic interest, (iii) proteins and peptides of forensic interest, (iv) dyes and inks, (v) forensic DNA. The present review collects and comments on 60 references.

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Application of dispersive liquid–liquid microextraction and CE with UV detection for the chiral separation and determination of the multiple illicit drugs on forensic samples

Cited by 53 publications

References 30 publications

Avaliação de fungos na obtenção do metabólito quiral e ativo fexofenadina

Avaliação de fungos na obtenção do metabólito quiral e ativo fexofenadina

Chiral Separations by Capillary Electrophoresis

Recent advances in the application of CE to forensic sciences, an update over years 2009–2011

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