2014
DOI: 10.1248/bpb.b14-00406
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Application of Dissolving Microneedles to Glucose Monitoring through Dermal Interstitial Fluid

Abstract: Dissolving microneedles (DMs) were applied to glucose monitoring in the dermal interstitial fluid (ISF) of rats and their potential as an alternative blood glucose monitoring device was evaluated. Sodium chondroitin sulfate was used to prepare DM array chips, which consisted of 300 DMs/cm 2 . The mean length of the DMs was 475 18 µm and the mean diameter of the basement was 278 8 µm. After DMs were inserted into the skin of the hair-removed rat abdomen, a wet unwoven cloth containing 10-30 µL of water was plac… Show more

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Cited by 20 publications
(12 citation statements)
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“…The potential of MN as a means of minimally-invasive means of TDM and diagnosis has recently become the focus of considerable interest [ 32 , 56 , 57 ]. Although previous studies have detected certain compounds using MN in combination with other techniques [ 57 ], no study has demonstrated the ability of MN alone to both detect and quantify analytes of clinical interest, thereby facilitating both diagnosis and TDM. In addition to theophylline, this study investigated the ability of hydrogel-forming MN to detect caffeine in vitro , using the previously-described Franz cell setup.…”
Section: Resultsmentioning
confidence: 99%
“…The potential of MN as a means of minimally-invasive means of TDM and diagnosis has recently become the focus of considerable interest [ 32 , 56 , 57 ]. Although previous studies have detected certain compounds using MN in combination with other techniques [ 57 ], no study has demonstrated the ability of MN alone to both detect and quantify analytes of clinical interest, thereby facilitating both diagnosis and TDM. In addition to theophylline, this study investigated the ability of hydrogel-forming MN to detect caffeine in vitro , using the previously-described Franz cell setup.…”
Section: Resultsmentioning
confidence: 99%
“…After a DMN array is stamped onto the skin, ISF can be obtained by applying negative pressure. Moreover, we successfully determined blood glucose levels and drug concentrations in ISF (16,17). To further ascertain the transport of AZM into the extravascular space, the present study was designed to measure total AZM concentrations in ISF of the skin of rats after intravenous administration of AZM by using DMNs.…”
mentioning
confidence: 99%
“…To investigate the distribution of macrolides in the ISF, ISF samples were collected from the abdominal skin of rats (with the hair removed) according to previously reported methods [10][11][12]. After IV administration of 5 mg/kg EM or 20 mg/kg CAM, 5 µL of ISF was collected from a pore on the abdominal skin formed by the DMN array chip with an applicator at 0.5, 1, 2, 3, 4, 5, 6, and 8 h after IV administration of drugs.…”
Section: Distribution Of Macrolides To Isfmentioning
confidence: 99%
“…Recently, we successfully obtained ISF samples directly from a pore on the skin using dissolving microneedles (DMNs) [10,11] and determined the total concentrations of azithromycin (AZM), a 15-membered ring macrolide antibiotic agent, in the ISF of the skin of rats [12]. Our results indicated that the high concentrations of AZM maintained in the ISF and skin are related to its potent antibiotic effects, whereas prolonged subinhibitory AZM levels at the target site contribute to the risk of AMR emergence.…”
Section: Introductionmentioning
confidence: 99%