In this work, p-type thermoelectric material was produced by hot extrusion of pre-synthesized in injection molding machine Bi0.5Sb1.5Te3 solid solution. During the research radial distribution of the Seebeck coefficient was confirmed and described in material’s cross section using thermal measuring probe. Such nonuniformity of the Seebeck coefficient is correlated with the strain-stress state of extrudate specifically with the distribution of accumulated strain intensity, which was obtained by mathematical modeling of extrusion process using the software package DEFORM.