Application of Electrosprayed Nanoparticles as Targeted Drug Delivery Systems: A Mini Review

Abstract

Nanoparticles (NPs) are referred to as tiny materials in size ranging from 1 to 100 nm. Unique characteristics of the NPs, including small sizes and high surface area, appropriate reactivity, proper stability, great strength, and many more, have resulted in their wide use in numerous fields. Among different techniques reported for synthesizing the nanoparticles, electro-hydrodynamic atomization or electrospray has been identified as a well-practiced and high efficient technique for the formation of fine and homogenous NPs from a liquid under the influence of electrical forces. This process allows feasible encapsulation of different drugs, vitamins, and proteins applicable in the targeted drug delivery systems. Since the release rate of the loaded pharmaceutical materials could be easily tuned via varying the properties of core and shell components. Herein, we summarized the importance of the electrospray technique for the production of drug-loaded nanoparticles applicable in controlled drug delivery systems.

The Antibacterial Activities of Copper Oxide Nanoparticles Synthesized Using Laser Ablation in Different Surfactants against Streptococcus mutans

“…In vivo, orthodontic retainers with AgNPs demonstrated a substantial antibacterial effect against S. mutans during deboning. Due to NPs' cellular toxicity and rising evidence of their potentially harmful effects, caution should be exercised in their widespread use [40,41].…”

Electrospray doxorubicin‐loaded polycaprolactone‐polyethylene glycol nanospheres/poloxamer‐chitosan thermogel: A promising candidate for clinical applications

“…Electrospray occurs when a liquid with adequate conductivity is passed through a capillary or nozzle to a high potential, forming single dispersed droplets 11 . Electrospray method holds significance in the synthesis of globular nanoparticles owing to its capacity to generate delicate and uniform particles with superior efficacy 12 . Electrospray additionally permits the encapsulation of hydrophobic and inadequately water‐soluble bioactive substances, bestowing regulated discharge characteristics and elevated encapsulation efficacy.…”

“…11 Electrospray method holds significance in the synthesis of globular nanoparticles owing to its capacity to generate delicate and uniform particles with superior efficacy. 12 Electrospray additionally permits the encapsulation of hydrophobic and inadequately water-soluble bioactive substances, bestowing regulated discharge characteristics and elevated encapsulation efficacy. In general, electrospray extends adaptability and potential in the formulation of globular nanoparticles for diverse implementations in medicinal and analytical chemistry.…”

Doxorubicin/poly(caprolactone)/polyethylene glycol nanoparticles prepared by electrospray

“…In the electrospray process, when the fluid exits the nozzle and enters the electric field, it forms a Taylor cone due to surface tension, and as the electric field increases, the Taylor cone turns into highly charged droplets 28 . This process enables the encapsulation of various drugs, vitamins, and proteins that can be used in targeted drug delivery systems 29–31 . Nano and microcapsules made of polycaprolactone (PCL) can be prepared using electrospray techniques for use in drug applications and growth factor release 32 .…”

“…28 This process enables the encapsulation of various drugs, vitamins, and proteins that can be used in targeted drug delivery systems. [29][30][31] Nano and microcapsules made of polycaprolactone (PCL) can be prepared using electrospray techniques for use in drug applications and growth factor release. 32 These capsules are good candidates due to their favorable properties.…”