This article presents a suite of response spectrum (RS) and Fourier amplitude spectrum (FAS) site amplification models for Central and Eastern North America (CENA). The amplification database used in model development was produced through large-scale one-dimensional site response analyses and overcomes limitations of prior databases by providing broader coverage of anticipated site conditions. New amplification functions conditioned on either VS30 or site natural period ( Tnat) as the primary independent variable are provided, the latter of which better captures features of the computed site amplification from the simulated database (i.e. model dispersion is reduced). Models for standard deviation also are developed. RS and FAS linear amplification functions that adjust the reference condition of VS = 3000 m/s to VS30 = 760 m/s, and account for amplification for profiles either with a sharp VS impedance or a more gradual increase in VS are also developed.