Application of External Fixation in Skull Surgery

Djachkov, Alexander Nikolaevich; Khudiaev, Alexander Timofeevich; Прудникова, О. Г.

doi:10.1007/978-88-470-2619-3_30

Cited by 1 publication

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the 112 patients with ischemic cerebral lesions of various causes, all the patients achieved regression of motor disorders more or less, positive sensory dynamics were detected in 85.7% of the patients following CBT treatment. 27 However, the biological mechanisms of CBT treatment remain largely unknown; nonetheless, these early clinical results suggest that CBT surgery was safe and effective in stimulating cerebral circulation and regression of neurological deficits in patients with stroke.…”

Section: Discussionmentioning

confidence: 99%

“…[22][23][24][25][26] Clinically, we only found one report from Russia to show that CBT treatment has enhanced cerebral circulation and contribute to regression of neurological deficits in patients with ischemic stroke. 27 Nonetheless, these findings inspire us to explore the possible use of CBT and potential underlying mechanisms for treatment of ischemic stroke.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Cranial Bone Transport Promotes Angiogenesis, Neurogenesis, and Modulates Meningeal Lymphatic Function in Middle Cerebral Artery Occlusion Rats

Bai

Pan

et al. 2022

Stroke

View full text Add to dashboard Cite

Background: Ischemic stroke is a leading cause of death and disability worldwide. However, the time window for quickly dissolving clots and restoring cerebral blood flow, using tissue plasminogen activator treatment is rather limited, resulting in many patients experiencing long-term functional impairments if not death. This study aims to determine the roles of cranial bone transport (CBT), a novel, effective, and simple surgical technique, in the recovery of ischemic stroke using middle cerebral artery occlusion (MCAO) rat model. Methods: CBT was performed by slowly sliding a bone segment in skull with a special frame and a speed of 0.25 mm/12 hours for 10 days following MCAO. Morris water maze, rotarod test, and catwalk gait analysis were used to study the neurological behaviors, and infarct area and cerebral flow were evaluated during CBT process. Immunofluorescence staining of CD31 and Nestin/Sox2 (sex determining region Y box 2) was performed to study the angiogenesis and neurogenesis. OVA-A647 (ovalbumin-Alexa Fluor 647) was intracisterna magna injected to evaluate the meningeal lymphatic drainage function. Results: CBT treatment has significantly reduced the ischemic lesions areas and improved the neurological deficits in MCAO rats compared with the rats in the control groups. CBT treatment significantly promoted angiogenesis and neurogenesis in the brain of MCAO rats. The drainage function of meningeal lymphatic vessels in MCAO rats was significantly impaired compared with normal rats. Ablation of meningeal lymphatic drainage led to increased neuroinflammation and aggravated neurological deficits and ischemic injury in MCAO rats. CBT treatment significantly improved the meningeal lymphatic drainage function and alleviated T-cell infiltration in MCAO rats. Conclusions: This study provided evidence for the possible mechanisms on how CBT attenuates ischemic stroke injury and facilitates rapid neuronal function recovery, suggesting that CBT may be an alternative treatment strategy for managing ischemic stroke.

show abstract

Section: Discussionmentioning

confidence: 99%