The characteristics of vibration and noise of an automobile have become important factors for evaluating automobiles. In this study, finite element modal analysis and harmonic analysis were used to analyze the dynamic characteristics of the bus bodywork. The analytical results show that vibration of ceiling board and floor board is large while the engine remains the idle running. The vibration of ceiling board and floor board are large during the engine running with the idle speed or the highest speed. In addition, the vibration of ceiling board and floor board also has peak values during the engine running with the maximum torsion moment. Therefore, for prediction of vehicle bodywork vibration and vehicle interior noise, the influence of the engine vibration on them should be considered in order to avoid resonance of bodywork boards and coupling of bodywork boards and interior acoustic field.