Application of Flexible OLED Display Technology for Electro-Optical Stimulation and/or Silencing of Neural Activity

Smith, John E.; O’Brien, Barry; Lee, Yong-Kyun; Bawolek, Edward J.; Christen, Jennifer Blain

doi:10.1109/jdt.2014.2308436

Cited by 51 publications

(41 citation statements)

References 22 publications

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“…We observed that by pulsing the power supply, the OLED operating voltage can be increased and subsequently significantly increase the instantaneous light intensity without degrading or damaging the OLED organic layers (Pulsed PD curve in figure 5). A continuous DC bias above 7 volts was shown to degrade the OLED organic emission layers due to current-induced, localized joule heating in the OLED organic layers [11,12].…”

Section: Discussionmentioning

confidence: 99%

Disposable point-of-use optical biosensor for multiple biomarker detection

Smith¹,

Katchman

Lee³

et al. 2014

2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings

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This work explored the viability of a new miniaturized fluorescence measurement-based sensor architecture using organic light emitting diode (OLED) display and photodiode active matrix array technology for point-of-use diagnosis of multiple disease biomarkers in a low cost disposable configuration. Sensor feasibility and optical performance were evaluated using a bright 0.3mW/mm 2 2 x 2 mm, 455nm blue OLED emitter test structure configured first with orthogonally crossed linear polarizing film; and second, with band-pass and long-pass optical filters. Preliminary measurement results indicated that this type of sensor architecture requires optical filters to approach the sensitivity of laboratory fluorescencebased instrumentation.

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Section: Discussionmentioning

confidence: 99%

Disposable point-of-use optical biosensor for multiple biomarker detection

Smith¹,

Katchman

Lee³

et al. 2014

2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings

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“…However, OLEDs are highly sensitive to water and oxidation [180] and leaking of nonbiocompatible organic components could be potentially toxic to the host. There are only a few reports using conventional OLEDs in close contact with biological matter [181]. OLED are mostly used as wearable light sources [182][183][184] and have not been implanted into tissue.…”

Section: Biomaterials Based Ledsmentioning

confidence: 99%

Toward biomaterial-based implantable photonic devices

et al. 2017

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Optical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.

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“…Luminance vs. voltage (L-V) data was collected using a Newport optics 818-UV photodiode and Keithley 2400 source meter, with measurement techniques defined by Forrest, et al [18,19].…”

Section: A High Intensity Flexible Green Oled Developmentmentioning

confidence: 99%

Application of Flexible OLED Display Technology to Point-of-Care Medical Diagnostic Testing

Smith

Katchman

Kullman

et al. 2016

J. Display Technol.

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This paper presents a new concept combining flexible organic light emitting diode (OLED) display technology with fluorescent biorecognition microarray technology to fabricate point-of-care immunobiosensors. Our approach is designed to leverage commercial OLED display technology to reduce pre-functionalized biosensor substrate costs to pennies per cm 2 combined with leveraging the display industries ability to manufacture an immense number of low-cost consumer electronic products annually. For this work, we demonstrate that our new approach using high brightness flexible OLED display technology combined with a charge integrating readout circuit and optical filters can offer point-of-care diagnostic sensitivity at or below 10 pg/mL, which approaches the lower limit of detection (LLOD) of typical clinical laboratory instrumentation.

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Application of Flexible OLED Display Technology for Electro-Optical Stimulation and/or Silencing of Neural Activity

Cited by 51 publications

References 22 publications

Disposable point-of-use optical biosensor for multiple biomarker detection

Disposable point-of-use optical biosensor for multiple biomarker detection

Toward biomaterial-based implantable photonic devices

Application of Flexible OLED Display Technology to Point-of-Care Medical Diagnostic Testing

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