In mining engineering, crack distribution has a considerable influence on the mechanical behavior and stability of the surrounding rock mass. Using the granite of the Sanshandao gold mine as experimental samples, the deformation and failure of fractured rock were analyzed based on a rock uniaxial compression test with acoustic emission monitoring. We analyzed the characteristics of different stages of rock sample deformation, and evaluated the failure mode of seven types of rock samples. The results show that the cracks had a considerable impact on rock sample strength and mechanical behavior, and the strength of intact rock was the highest, while that of the sample with parallel double cracks was the lowest. The acoustic emission parameters, AF, RA, and lg(AF/RA), have different change trends in different stages of rock deformation and failure. Based on these change trends, the failure modes of rock samples with different crack distributions were identified. Additionally, for the rock samples with seven types of crack distribution, a sudden or progressive failure caused by the b-value curves was observed. The research findings provide a database for deep surrounding rock stability in the study area and provide suggestions for failure prediction.