Application of gradient high-performance liquid chromatography to the analysis of some multicomponent pharmaceutical preparations

Голубицкий, Г. Б.; Basova, E. M.; Иванов, В. М.

doi:10.1134/s1061934808090141

Cited by 7 publications

(5 citation statements)

References 1 publication

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“…Different analytical techniques were applied for the determination of OXM; among them are spectrophotometric [4–6], spectrofluorometric [6, 7], chemiluminescence [8, 9], HPLC [10–16] and electrochemical methods [17, 18].…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Analysis of Oxymetazoline Hydrochloride at Zeolite – Modified Carbon Paste Electrode in Micellar Medium

et al. 2021

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Simple, sensitive, accurate and inexpensive differential pulse (DPV) and square wave (SWV) voltammetric methods utilizing zeolite modified carbon paste electrode (ZMCPE) were developed for the determination of Oxymetazoline hydrochloride (OXM) in nasal drops. Various experimental parameters were optimized using cyclic voltammetry (CV). Calibration curves were linear over the concentration ranges 9.8×10−8–3.6×10−6 M and 9.8×10−6–9×10−5 M for DPV and SWV, respectively. The DPV method showed a limit of detection (LOD) of 1.04×10−7 M. The method was applied for the determination of OXM in pharmaceutical formulation with an average recovery of 101.18 % (%RSD=0.41, n=9).

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Section: Introductionmentioning

confidence: 99%

Voltammetric Analysis of Oxymetazoline Hydrochloride at Zeolite – Modified Carbon Paste Electrode in Micellar Medium

et al. 2021

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“…Consequently, spectrophotometric [4][5][6][7], high performance liquid chromatographic (HPLC) [8][9][10][11][12], chemiluminescence [13,14] and potentiometric methods [15] have been suggested for the determination of OXM. Some of the proposed spectrophotometric methods use either tedious lengthy calculations or they are highly dependent on the selection of the wavelength region which critically affects the precision and accuracy.…”

Section: Introductionmentioning

confidence: 99%

All-solid-state polymeric screen printed and carbon paste ion selective electrodes for determination of oxymetazoline in pharmaceutical dosage forms

et al. 2019

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All-solid state potentiometric ion selective electrodes have the merits of being portable, small and suitable for small volume samples. Herein, disposable home-made screen printed polymeric ion selective electrode (SPE) is developed for determination of oxymetazoline (OXM) in pharmaceutical nasal drops and drug substance. Ion selective electrodes with optimal potentiometric response were achieved by careful selection of the ion exchanger and plasticizer. A screen printed electrode utilizing oxymetazoline-tetraphenyl borate (OXM-TPB) as an ion exchanger and dibutyl phthalate (DBP) as a plasticizer exhibited a Nernstian slope of 59.5±0.5 mV/decade (n=3) over the concentration range from 1×10-5 to 1×10-2 M OXM (r = 0.9999) with a detection limit of 5.0×10-6 M. The electrode is useful over a wide pH range from 4.0 to 8.0. The electrode showed a high selectivity for OXM against several common interfering ions. The potential interference from benzalkonium chloride was easily eliminated by treatment the sample with KI. Comparable potentiometric characteristics including linearity, detection limit, pH range and selectivity pattern were obtained with a carbon paste electrode (CPE) comprising same ion exchanger and plasticizer. The electrodes were successfully used for the assay of OXM in the drug substance and in the dosage form in presence of benzalkonium chloride with high accuracy (±2%) and precision (%RSD ˂2.5). The proposed method is simple, accurate and precise.

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“…It is generally used in the nasal cavity as a decongestant [25,26] and can be used in combination therapies for a wide variety of ear, nose and throat disorders [25][26][27]. The drug has a relatively low molecular weight, much of which is contained within the chromophore structure itself.…”

Section: Metronidazolementioning

confidence: 99%

“…This drug is often used in ointments and sprays and therefore ability to quantify release through HPLC is of great value. Analysis is traditionally performed using a C18 column with detection at 230 nm [25][26][27].…”

Section: Metronidazolementioning

confidence: 99%

Development and Utilization of Reversed Phase High Performance Liquid Chromatography Methods for a Series of Therapeutic Agents

Corbett¹

2013

Mod Chem Appl

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Capability to quantify drug release is vital in many areas of pharmaceutical research. Accurate, rapid and repeatable detection of pharmaceutical agents allows for comparisons between drug delivery constructs prior to in vivo studies as well as identification of therapeutic levels in samples both in vitro and in vivo. Perhaps the foremost scientific method for monitoring of therapeutics is High Performance Liquid Chromatography. This process allows for clear and simple quantification of therapeutic presence in a sample, with an inherent or induced chromophore, through the detection of bound specimen to the utilized column. Multiple drugs can be used through this process and exemplary methods are presented for the pharmaceutics; cefuroxime, clindamycin, dexamethasone, dicloxacillin, doxycycline, metronidazole, oxymetazoline, paclitaxel, tobramycin, and vancomycin. Each of these drugs is analyzed using Reversed-Phase High Performance Liquid Chromatography utilizing a hydrophobic column. Independent, repeatable methods are developed for each drug. Where necessary a pre-column derivatization is used to allow for visualization of otherwise undetectable tobramycin. In the case of each drug, a standard curve is presented to show the linearity of response for the proposed method within a range of absorbance. This work shows the ability to analyze multiple drugs with a single simple, quick, cost effective system and detection methods are evaluated for each drug with a R 2 value of greater than 0.99.

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Application of gradient high-performance liquid chromatography to the analysis of some multicomponent pharmaceutical preparations

Cited by 7 publications

References 1 publication

Voltammetric Analysis of Oxymetazoline Hydrochloride at Zeolite – Modified Carbon Paste Electrode in Micellar Medium

Voltammetric Analysis of Oxymetazoline Hydrochloride at Zeolite – Modified Carbon Paste Electrode in Micellar Medium

All-solid-state polymeric screen printed and carbon paste ion selective electrodes for determination of oxymetazoline in pharmaceutical dosage forms

Development and Utilization of Reversed Phase High Performance Liquid Chromatography Methods for a Series of Therapeutic Agents

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