Application of heart rate variability to determine physiologic changes in hypothermic rats

Bastille, Amy M

doi:10.1016/s0306-4565(04)00030-0

Cited by 1 publication

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“…An in vivo study demonstrated that hypothermic rats had increased SDNN, which peaked when T co was approximately 30°C [117]; this response resulted in mortality for some rats. There were no corresponding changes in the power spectral density, suggesting that the elevation in HRV may have occurred without significant ANS input.…”

Section: Hypothermic Responsementioning

confidence: 99%

Heart rate variability in rodents: uses and caveats in toxicological studies

et al. 2007

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Heart rate variability (HRV) is a measure of cardiac pacing dynamics that has recently garnered a great deal of interest in environmental health studies. While the use of these measures has become popular, much uncertainty remains in the interpretation of results, both in terms of human and animal research. In humans, HRV endpoints, specifically chronic alterations in baseline HRV patterns, have been reasonably well characterized as prognostic indicators of adverse outcomes for a variety of diseases. However, such information is lacking for reversible HRV changes that may be induced by short-term exposures to environmental toxicants. Furthermore, there are minimal substantive data, either acute or chronic, regarding the pathological interpretation or prognostic value of toxicant-induced changes in HRV in rodents. The present report summarizes the physiological and clinical aspects of HRV, the methodological processes for obtaining these endpoints, and previous human and animal studies in the field of environmental health. Furthermore, we include a discussion of important caveats and recommendations for the interpretation of HRV data in animal research.

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Section: Hypothermic Responsementioning

confidence: 99%