Application of ionic liquids as mobile phase additives and surface-bonded stationary phase in liquid chromatography

Abstract

Ionic liquids (ILs) have gained wide recognition as novel solvents in chemistry. Their application in analytical chemistry, especially in separating analytes, is warranted due to their unique properties such as negligible vapor pressure, good thermal stability, tunable viscosity and miscibility with water and organic solvents, as well as good extractability for various organic compounds and metal ions. Recently, some new chromatographic separation media, formed by combining ILs on silica and polymer surface using covalently or non-covalently interaction, have been developed and applied to biological separation and environment analysis. This review will focus on some of the properties of ILs and their potential application as mobile phase modifier and surface-bonded stationary phase in high-performance liquid chromatography (HPLC) separation.

A Simple Correlation for Estimating the Viscosity of Pure Ionic Liquids and Their Binary Mixtures

“…The replacement of conventional solvents with ionic liquids is the subject of many research projects around the world. Ionic liquids have been applied in various fields such as in enzymatic reactions, electrochemistry, pharmaceuticals, liquid extraction, , solvent extraction, solar cells and batteries, , liquid chromatography, gas chromatography, electrophoresis, , and sensors …”

High-pressure phase behavior of binary mixtures containing methylpyrrolidinium derivative ionic liquids and carbon dioxide

“…For this reason, ionic liquids and their advantages have received great attention recently as a green solvent in various chemical industries [3,4]. In addition, ionic liquids have been widely considered as alternatives to classical organic solvents and have been applied in electrochemistry, organic synthesis, liquid phase extraction and catalysis for clean technology [5]. Recent researches have shown that ionic liquids are used in membrane-based systems for separation processes and liquid-liquid separation processes [6,7].…”

Extraction and Determination of Quercetin and Myricetin from Chamaecyparis obtusa by Ionic Liquids‐based Monolithic Cartridge

“…[18][19][20] According to literatures, 21,22 a butylimidazolium-based phase was shown to exhibit remarkable reversed-phase retention properties emanating from the imidazolium ring. Firstly, 6.0 g 1-chlorobutane and 4.2 g imidazole were added into a dry round bottom flask containing a magnetic stir bar, and then 50.0 mL toluene was added as solvent.…”