Application of Ionic Liquids in High Performance Reversed-Phase Chromatography

Abstract

Ionic liquids, considered “green” chemicals, are widely used in many areas of analytical chemistry due to their unique properties. Recently, ionic liquids have been used as a kind of novel additive in separation and combined with silica to synthesize new stationary phase as separation media. This review will focus on the properties and mechanisms of ionic liquids and their potential applications as mobile phase modifier and surface-bonded stationary phase in reversed-phase high performance liquid chromatography (RP-HPLC). Ionic liquids demonstrate advantages and potential in chromatographic field.

Removal of chromium from industrial effluents using nanotechnology: a review

“…The imidazolium ring can be covalently bonded onto silica, linked by alkyl group chains (provided by silane-coupling agents). These alkyl branches can be attached to different positions of the imidazolium ring [81]. In a study by Whang et al [82], imidazolemodified silica adsorbent with chloride as counter ion (SilprIm-Cl) was used to adsorb Cr(VI) with a maximum capacity of 47.79 mg/g (from an initial concentration of 150 mg/l) at pH of 2.…”

Ionic Liquid–Liquid Chromatography: A New General Purpose Separation Methodology

“…However, ammonium and phosphonium cation ionic liquids can be used over the whole 200-to 800-nm range of modern UV-Vis spectrophotometers. Anions (such as chloride) can also be used over the 2005 [52] 2006 [53] 2007 [54] 2007 [55] 2007 [56] 2008 [24] 2008 [57] 2009 [58] 2010 [59] 2011 [60] 2012 [61] 2014 [62] 2016 [63] The use of ionic liquids in capillary electrophoresis and related technology 2004 [64] 2006 [65] 2008 [66] 2009 [67] 2013 [68] 2014 [69] 2016 [63] The use of chiral ionic liquids in chromatography 2005 [70] 2008 [71] 2008 [72] 2012 [73] 2014 [74] The use of ionic liquids in CCC 2008 [24] 2013 [75] The use of ionic liquids in GC 2009 [76] 2009 [77] 2011 [78] 2014 [79] 2014 [80] 2016 [81] 2016 [82] The use of ionic liquids in HPLC 2006 [83] 2009 [84] 2011 [85] 2012 [86] 2012 [87] 2015 [88] full 200-to 800-nm range, but anions such as triflate or bis{(trifluoromethyl)sulfonyl}amide absorb light at wavelengths below 250 nm. Coloured impurities in the ionic liquid can also affect the performance of the UV-Vis detector, but these can be removed by filtering the ionic liquid through charcoal [...…”

Versatile ligands for high-performance liquid chromatography: An overview of ionic liquid-functionalized stationary phases

“…There are a substantial amount of publications involving SCIL SPs in HPLC [42][43][44][45][46][47][48][49][50][51]. In spite of the variation in their morphology upon immobilization, the characteristics depending on the structure of the cation, anion and the subsituents can be maintained for modification of the silica support.…”