Application of Maltodextrin as Chiral Selector in Capillary Electrophoresis for Quantification of Amlodipine Enantiomers in Commercial Tablets

Nojavan, Saeed; Pourmoslemi, Shabnam; Behdad, Hamideh; Fakhari, Ali Reza; Mohammadi, Ali

doi:10.1002/chir.22334

Cited by 17 publications

(16 citation statements)

References 25 publications

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“…Also a combined chiral selector system containing a neutral polysaccharide (glycogen), a ionic polysaccharide (chondroitin sulfate), β-CD and HP-β-CD, respectively, exhibited good enantioselective properties towards AML enantiomers analysis (Chen et al, 2010). As an alternative to CDs maltodextrin was successfully used as chiral selector in CE for the enantioseparation of AML from pharmaceuticals (Nojavan et al, 2014). Also, polybrene, a cationic polymer, was used to improve AML enantioseparation by CE (Zandkarimi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Chiral discrimination of amlodipine from pharmaceutical products using capillary electrophoresis

Cârcu-Dobrin

Sabău

Hancu

et al. 2020

Braz. J. Pharm. Sci.

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The present work describes the development of a capillary electrophoresis (CE) method for the chiral discrimination of amlodipine (AML) enantiomers using cyclodextrine (CD) derivatives as chiral selectors. A large number of native and derivatized, neutral and ionized CD derivatives were screened to find the optimal chiral selector; and carboximethyl-β-CD (CM-β-CD) was selected for the enantiomeric discrimination. A factorial analysis study was performed by orthogonal experimental design in which several factors were varied at the same time to optimize the separation method. The optimized method (25 mM phosphate buffer, pH = 9.0, 15 mM CM-β-CD, 15 °C, + 25 kV, 30 mbar/1 second, detection wavelength 230 nm) was successfully applied for the baseline separation of AML enantiomers within 5 minutes. Successful validation and application of the proposed CE method suggest its routine use in enantioselective control of AML in pharmaceutical preparations.

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Section: Introductionmentioning

confidence: 99%

Chiral discrimination of amlodipine from pharmaceutical products using capillary electrophoresis

Cârcu-Dobrin

Sabău

Hancu

et al. 2020

Braz. J. Pharm. Sci.

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“…By employing different chiral selectors , the interactions between chiral analytes and chiral selectors can be adjusted, resulting in the effective separation of chiral compounds. These chiral selectors, which are usually utilized as additives in the buffer or stationary phase in the capillary to form CEC systems, include cyclodextrins , cyclofructans , polysaccharides , celluloses , polymeric surfactants , antibiotics and many other molecules.…”

Section: Introductionmentioning

confidence: 99%

Covalent bonding of homochiral metal‐organic framework in capillaries for stereoisomer separation by capillary electrochromatography

2015

Electrophoresis

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In this work, a [Cu(mal)(bpy)]⋅H2O (mal, L-(-)-malic acid; bpy, 4,4'-bipyridyl) homochiral metal-organic frameworks (MOFs) was synthesized and used for modifying the inner walls of capillary columns by utilizing amido bonds to form covalent links between the MOFs particles and capillary inner wall. The synthesized [Cu(mal)(bpy)]⋅H2 O and MOFs-modified capillary column were characterized by X-ray diffraction, thermogravimetric analysis, particle size distribution analysis, nitrogen absorption characterization, FTIR spectroscopy, SEM, and energy-dispersive X-ray spectroscopy (EDX). The MOFs-modified capillary column was used for the stereoisomer separation of some drugs. The LODs and LOQs of six analytes were 0.1 and 0.25 μg/mL, respectively. The linear range was 0.25-250 μg/mL for ephedrine, 0.25-250 μg/mL for pseudoephedrine, 0.25-180 μg/mL for D-penicillamine, 0.25-120 μg/mL for L-penicillamine, 0.25-180 μg/mL for D-phenylalanine, and 0.25-160 μg/mL for L-phenylalanine, all with R(2) > 0.999. Finally, the MOFs-modified capillary column was applied for the analysis of active ingredients in a real sample of the traditional Chinese medicine ephedra.

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“…Recently, the use of CE has rapidly spread into a wide array of analytical areas, such as chiral separation. This is attributed to its simplicity, high efficiency, and low cost, as well as its high flexibility in selecting types of chiral selectors (CSs) .…”

Section: Introductionmentioning

confidence: 99%

Combined use of l‐alanine tert butyl ester lactate and trimethyl‐β‐cyclodextrin for the enantiomeric separations of 2‐arylpropionic acids nonsteroidal anti‐inflammatory drugs

Mavroudi

Kapnissi‐Christodoulou

2015

Electrophoresis

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In this study, a new CE method, employing a binary system of trimethyl-β-CD (TM-β-CD) and a chiral amino acid ester-based ionic liquid (AAIL), was developed for the chiral separation of seven 2-arylpropionic acid nonsteroidal anti-inflammatory drugs (NSAIDs). In particular, the enantioseparation of ibuprofen, ketoprofen, carprofen, indoprofen, flurbiprofen, naproxen, and fenoprofen was improved significantly by supporting the BGE with the chiral AAIL l-alanine tert butyl ester lactate (l-AlaC4 Lac). Parameters, such as concentrations of TM-β-CD and l-AlaC4 Lac, and buffer pH, were systematically examined in order to optimize the chiral separation of each NSAID. It was observed that the addition of the AAIL into the BGE improved both resolution and efficiency significantly. After optimization of separation conditions, baseline separation (Rs >1.5) of five of the analytes was achieved in less than 11 min, while the resolution of ibuprofen and flurbiprofen was approximately 1.2. The optimized enantioseparation conditions for all analytes involve a BGE of 5 mM sodium acetate/acetic acid (pH 5.0), an applied voltage of 30 kV, and a temperature of 20°C. In addition, the results obtained by computing the %-RSD values of the EOF and the two enantiomer peaks, demonstrated excellent run-to-run, batch-to-batch, and day-to-day reproducibilities.

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Application of Maltodextrin as Chiral Selector in Capillary Electrophoresis for Quantification of Amlodipine Enantiomers in Commercial Tablets

Cited by 17 publications

References 25 publications

Chiral discrimination of amlodipine from pharmaceutical products using capillary electrophoresis

Chiral discrimination of amlodipine from pharmaceutical products using capillary electrophoresis

Covalent bonding of homochiral metal‐organic framework in capillaries for stereoisomer separation by capillary electrochromatography

Combined use of l‐alanine tert butyl ester lactate and trimethyl‐β‐cyclodextrin for the enantiomeric separations of 2‐arylpropionic acids nonsteroidal anti‐inflammatory drugs

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