Application of methane and hydrogen-based breath test in the study of gestational diabetes mellitus and intestinal microbes

Zhang, Miao; Xu, Yajuan; Zhang, Jingzhe; Sun, Zongzong; Ban, Yanjie; Wang, Biao; Hou, Xiaofeng; Cai, Yanjun; Li, Jingjing; Wang, Meng-Qi; Wang, Wentao

doi:10.1016/j.diabres.2021.108818

Cited by 12 publications

(11 citation statements)

References 22 publications

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“…The diagnostic criteria are as follows (Jani & Marsicano, 2018;Schiller et al, 2017;Zhang et al, 2021)…”

Section: Diagnostic Methods For Gastrointestinal Symptomsmentioning

confidence: 99%

“…The experimental steps are as follows (Liu et al., 2016 ; Zhang et al., 2021 ): (1) 12 h before the test, all subjects were allowed to consume eggs, skinless chicken and fish, beef, and white rice. Dairy products, soy products, and other foods that tend to produce gas or are rich in fiber are prohibited; (2) on the day of the test, tooth brushing and mouth rinsing were required.…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of probiotics in the treatment of hypothyroidism in early pregnancy combined with small intestinal bacterial overgrowth

Zhang,

Xu,

Sun

et al. 2024

Food Science & Nutrition

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The aim of this study was to investigate the association between hypothyroidism in early pregnancy and small intestinal bacterial overgrowth (SIBO) and the effect of probiotics. Patients with hypothyroidism in early pregnancy and normal pregnant women during the same period were included in the methane–hydrogen breath test to compare the incidence of SIBO, smoothed curve fit, and differences in clinical symptoms. For those who combined with SIBO, the rate of clinical symptom conversion, thyroid hormones, and changes in associated inflammatory indexes were compared after 21 days of treatment with probiotics on top of conventional levothyroxine sodium tablets. The results are as follows: (1) The incidence of combined SIBO in patients with hypothyroidism in pregnancy was 56.0%, significantly higher than the 28.0% of normal pregnant women during the same period. (2) The highest value of hydrogen plus methane gas in 90 min in pregnancy hypothyroid patients showed a significant negative correlation with FT4 (p < .001, SD = 0.169). (3) Abdominal distension symptoms were significantly increased in both groups after combined SIBO (p = .036, p = .025), and the conversion rate after treatment was 69.2% and 75.0%, respectively. (4) In hypothyroidism, pregnancy combined with SIBO, TSH, and CRP was higher before treatment (p = .001, p = .012) and decreased significantly after treatment (p = .001, p = .008). Hypothyroidism in early pregnancy is associated with SIBO, and probiotic treatment is significantly effective.

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“…The diagnostic criteria are as follows (Jani & Marsicano, 2018;Schiller et al, 2017;Zhang et al, 2021)…”

Section: Diagnostic Methods For Gastrointestinal Symptomsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Evaluation of probiotics in the treatment of hypothyroidism in early pregnancy combined with small intestinal bacterial overgrowth

Zhang,

Xu,

Sun

et al. 2024

Food Science & Nutrition

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“…Repeated abdominal distension or overt atulence on at least three days per month over the previous three months are required for the diagnosis of abdominal distension; Although the criteria for FD, IBS, or other FGIDs weren't met, they were met in the most recent three months when symptoms started showing up at least six months prior to diagnosis [12]. Increased bowel movements (more than three times daily) and altered stool composition (paste liquid) are symptoms of diarrhea [16].…”

Section: Diagnostic Methods Of Clinical Symptomsmentioning

confidence: 99%

“…Exhalations were then collected every 20 minutes. Plot the hydrogen and methane abundance time curves [12].…”

Section: Hydrogen/methane Lactulose Breath Test (Lbt)mentioning

confidence: 99%

Association between hypothyroidism in early pregnancy and small intestinal bacterial over growth: a case control study

Zhang

Ban

et al. 2022

Preprint

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Objective Using a hydrogen coupled methane lactulose breath test (LBT) and associated clinical indices, the link between small intestinal bacterial overgrowth (SIBO) and hypothyroidism in early pregnancy. Methods The methane hydrogen breath test included 200 patients with early-stage hypothyroidism, 200 normal pregnant women, 200 normal women of childbearing age prior to pregnancy. Comparisons were made between the incidence, smooth curve fitting, clinical signs, and clinical test results of SIBO. Results The positive rates of SIBO were 62.00%, 28.50%, and 20.50%, respectively, in the hypothyroidism during pregnancy group, the normal pregnant women group, and the normal women group before pregnancy. p < 0.001 indicates that the difference was statistically significant. Additionally, thyrotropin (TSH) and methane hydrogen exhalation volume showed a positive connection in patients with hypothyroidism during pregnancy (p < 0.01, Std = 0.163).In the three groups, the abdominal distension symptoms of patients with SIBO were significantly higher than those of patients without SIBO(p = 0.017,p < 0.001,p < 0.001).Patients with hypothyroidism complicating SIBO had greater levels of TSH, TPOAb, C-reactive protein, and FT4, whereas their levels of vitamin D were decreased(p < 0.001,respectively).Conclusion Intestinal bacterial overgrowth and hypothyroidism during the first trimester and pregnancy are closely associated; the connection between these two conditions may also involve inflammatory agents and vitamin levels.

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“…It has been shown that oral administration of lactulose increases the synthesis of H 2 by bacteria of the gastrointestinal tract [ 53 ]. Moreover, a hydrogen breathing test has been proposed to determine the state of the intestinal microflora by its ability to generate molecular hydrogen [ 54 ]. It is important to emphasize that hydrogen is synthesized by microorganisms together with other gases (for example, methane) [ 55 ].…”

Section: Routes Of Introducing Molecular Hydrogen Into the Bodymentioning

confidence: 99%

Molecular Hydrogen: From Molecular Effects to Stem Cells Management and Tissue Regeneration

Artamonov

Мартусевич

Pyatakovich³

et al. 2023

Antioxidants

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It is known that molecular hydrogen is a relatively stable, ubiquitous gas that is a minor component of the atmosphere. At the same time, in recent decades molecular hydrogen has been shown to have diverse biological effects. By the end of 2022, more than 2000 articles have been published in the field of hydrogen medicine, many of which are original studies. Despite the existence of several review articles on the biology of molecular hydrogen, many aspects of the research direction remain unsystematic. Therefore, the purpose of this review was to systematize ideas about the nature, characteristics, and mechanisms of the influence of molecular hydrogen on various types of cells, including stem cells. The historical aspects of the discovery of the biological activity of molecular hydrogen are presented. The ways of administering molecular hydrogen into the body are described. The molecular, cellular, tissue, and systemic effects of hydrogen are also reviewed. Specifically, the effect of hydrogen on various types of cells, including stem cells, is addressed. The existing literature indicates that the molecular and cellular effects of hydrogen qualify it to be a potentially effective agent in regenerative medicine.

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Application of methane and hydrogen-based breath test in the study of gestational diabetes mellitus and intestinal microbes

Cited by 12 publications

References 22 publications

Evaluation of probiotics in the treatment of hypothyroidism in early pregnancy combined with small intestinal bacterial overgrowth

Evaluation of probiotics in the treatment of hypothyroidism in early pregnancy combined with small intestinal bacterial overgrowth

Association between hypothyroidism in early pregnancy and small intestinal bacterial over growth: a case control study

Molecular Hydrogen: From Molecular Effects to Stem Cells Management and Tissue Regeneration

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