Application of Microfluidic Chip Technology in Food Safety Sensing

Gao, Hong-Wei; Yan, Chunlei; Wu, Wei; Li, Juan

doi:10.3390/s20061792

Cited by 66 publications

(34 citation statements)

References 109 publications

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“…Mask were made according to the designed pattern and the channel template was fabricated by spin-coating su8-3025 photoresist, after silane treatment was carried out for 5 min, PDMS was poured into the chip, horizontal standing for 30 min, and baked in 80°C electric drying oven for 10 min. Then clean the silicon wafer for plasma cleaning, the upper and lower layers of chips were irreversibly bonded, and the chip production was completed [ 28 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

Microfluidics for the rapid detection of Staphylococcus aureus using antibody-coated microspheres

et al. 2020

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Staphylococcus aureus is a common foodborne pathogenic microorganism which can cause food poisoning and it is pathogenic to both humans and animals. Therefore, rapid detection of S. aureus infection is of great significance. In this study, a microfluidic platform was introduced to detect S. aureus by fluorescence labeling method and a self-made microfluidic chip, which has immune spheres were used to study the effect of capturing S. aureus . Through this experiment, we found that the platform can be used for microbial culture, and S. aureus antibody coated on the diameter of 50 ~ 90 μm microspheres for detection. On the premise of optimizing the sample flow rate and detection time, the bacterial detection was quantitatively monitored. Results showed that our platform can detect S. aureus at injection rate of 5 μL·min −1 reacted for 4 min and the detection limit of bacteria is 1.5 × 10 1 CFU/μL. However, the detection time of traditional method is 24 hs to 72 hs, and the operation is complex and cumbersome. These findings indicated that the microfluidic chip in this study is portable, sensitive, and accurate, laying a good foundation for further research on the application of rapid bacterial detection platform.

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Section: Methodsmentioning

confidence: 99%

Microfluidics for the rapid detection of Staphylococcus aureus using antibody-coated microspheres

et al. 2020

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“…Recently, Gao et al. (2020) reviewed the classification, materials, processing, and applications of microfluidic chips in food safety sensing. However, there is no review focusing on the fluid driving mode of microfluidic chips for detecting food contaminants, including pesticides, antibiotics, and toxic substances.…”

Section: Introductionmentioning

confidence: 99%

Computer simulation of submicron fluid flows in microfluidic chips and their applications in food analysis

Xie

Sun

2021

Comp Rev Food Sci Food Safe

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In recent years, countries around the world have maintained a zero‐tolerance attitude toward safety problems in the food industry. In order to ensure human health, a fast, sensitive, and high‐throughput analysis of food contaminants is necessary to ensure safe food products on the market. Microfluidics, as a high‐efficiency and sensitive detection technology, has many advantages in the detection of food contaminants, including foodborne pathogens, pesticides, heavy metal ions, toxic substances, and so forth, especially in conjunction with a variety of submicron fluid driving methods, making food detection and analysis more efficient and accurate. This review introduces the principle of submicron fluid driving modes and discusses the driving simulation of submicron fluid in microfluidic chips. In addition, the latest developments in the application of simulation in food analysis from 2006 to 2020 are discussed, and the computer simulation of submicron fluid flow in microfluidic chips and its application and development trend in food analysis are also highlighted. The review indicates that microfluidic technology, using numerical simulation as an auxiliary tool, combined with traditional methods has greatly improved the detection and analysis of food products. In addition, microfluidics combined with a variety of control methods embodies the ability of specific, multifunctional, and sensitive detection and analysis of food products. The development of high‐sensitivity, high‐throughput, portable, integrated microfluidic chips will enable the technology to be applied in practice.

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“…However, over the past several years, a lot of research and resources have been dedicated to developing new paper-based devices, or improving their performance, for use in a wide range of applications. Paper-based devices have been used for biomedical applications [3], food safety [4], soil analysis [5], water analysis [6] and in many other miscellaneous applications [7]. Muller et al [8] may have developed the first simple paper-based microfluidic device in 1949 [9] [10] [11]; however, it was the Whitesides group in 2007 [12] who gave a renewed view and push for the possible applications of this technology.…”

Section: Introductionmentioning

confidence: 99%

Literature Review of the Use of Zinc and Zinc Compounds in Paper-Based Microfluidic Devices

Charbaji¹,

Heidari-Bafroui²,

Anagnostopoulos³

et al. 2021

JMMCE

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Zinc and its compounds, alloys and composites play an important role in the modern day world and find application in almost every aspect that can improve the quality of our lives. This ranges from supplements and pharmaceuticals that are meant to improve our health and wellbeing to additives meant to guard or reduce corrosion in metals. However, over the past several years, a new area of technology has been garnering a great deal of attention and has made use of zinc and its compounds. This is with reference to paper-based microfluidic technology that offers several advantages and that keeps expanding in the amount of applications it covers. In this paper, a review is offered for the applications that have used zinc or zinc compounds in paper-based microfluidic devices.

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Application of Microfluidic Chip Technology in Food Safety Sensing

Cited by 66 publications

References 109 publications

Microfluidics for the rapid detection of Staphylococcus aureus using antibody-coated microspheres

Microfluidics for the rapid detection of Staphylococcus aureus using antibody-coated microspheres

Computer simulation of submicron fluid flows in microfluidic chips and their applications in food analysis

Literature Review of the Use of Zinc and Zinc Compounds in Paper-Based Microfluidic Devices

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