Application of Molecular Techniques in Quality Control of Drugs of Natural Origin; A Review

Butt, Juwairiya; Arshad, Sana; Mir, Zulfiqar Ali; Awais, Sophia; Iqbal, Javed; Saeed-Ul-Hassan,

doi:10.9734/jpri/2017/38523

Cited by 2 publications

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“…Furthermore, DNA‐based techniques are utilised for quality control of herbal drugs. DNA molecular profiling is used to identify species and different constituents present in a herbal drug 22 . Noteworthy is the recent application of chemometrics in the quality control of herbal drugs 23–27 .…”

Section: Introductionmentioning

confidence: 99%

“…DNA molecular profiling is used to identify species and different constituents present in a herbal drug. 22 Noteworthy is the recent application of chemometrics in the quality control of herbal drugs. [23][24][25][26][27] A combination of the chemical profiling methods including chromatography and spectroscopy together with chemometric analysis is advised as a quality control tool for either evaluation or standardisation of herbal products.…”

Section: Introductionmentioning

confidence: 99%

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Advances in the quality control of fenugreek seeds using chromatographic, spectroscopic and DNA‐based techniques: A comprehensive review

Kandil

Ayoub

El-Ahmady

et al. 2021

Phytochemical Analysis

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Introduction Fenugreek has been used in traditional remedies since ancient times. It has a long history of use against medical ailments as an antidiabetic, anticarcinogenic, hypocholesterolemic, antioxidant, antibacterial, hypoglycemic, gastric stimulant, and anti‐anorexia agent. The major active constituents include alkaloids, fibres, saponins, proteins, and amino acids. Objectives To provide a comprehensive overview of the application of chromatographic and spectroscopic methods, in addition to DNA‐profiling methods to assess the quality of fenugreek. Also, to highlight the recent application of chemometrics combined with quality control methods during the last two decades. Methodology A literature search conducted from January 2000 up to December 2020 using various scientific databases (e.g., Scopus, Medline, PubMed, EBSCO, JSTOR, ScienceDirect, Google Scholar, Web of Science and Egyptian Knowledge Bank, Academic Journals, and Springer Link); general web searches were also undertaken using Google applying some related search terms. Studies involving the application of quality control analyses were classified into three categories according to the conducted analysis method including chromatographic [high‐performance liquid chromatography (HPLC), high‐performance thin‐layer chromatography (HPTLC), and gas chromatography (GC)], spectroscopic [ultraviolet (UV), infrared (IR), and nuclear magnetic resonance (NMR)], and DNA‐based markers. Results This review shed the light on relevant studies covering the past two decades, presenting the application of spectroscopic and chromatographic methods and DNA profiling in the quality control of fenugreek. Conclusion The reviewed chromatographic and spectroscopic methods combined with chemometrics provide a powerful tool that could be applied widely for the quality control of fenugreek.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Advances in the quality control of fenugreek seeds using chromatographic, spectroscopic and DNA‐based techniques: A comprehensive review

Kandil

Ayoub

El-Ahmady

et al. 2021

Phytochemical Analysis

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Pharmacognosy and Its Role in the System of Profile Disciplines in Pharmacy

Cahlíková

Šafratová

Hošťálková

et al. 2020

Natural Product Communications

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The primal discipline from which pharmacy has developed can be considered as pharmacognosy. This review defines pharmacognosy while reflecting on the latest development and discourse about its justifiability in the educational system in pharmaceutical faculties and the history of development of new drugs under the influence of pharmacognosy. The article defines the status quo of the pharmacognosy area, or more precisely its parts (biology, chemistry, production, and technology) and discusses their connections. It underlines the legitimacy of application of natural drugs in therapy, which is undeniable, and proves that whether a new drug was prepared either synthetically or isolated from a natural source is not important. The overview follows the basic requirements of pharmacognosy, especially its methodology (usage of faster and more effective phyto-analytical methods, reverse pharmacology, and reverse pharmacognosy, in silico methods). Pharmacognosy is confronted by three major challenges in the 21st century that can push it significantly forward: ethnopharmacological sources evaluation, evaluation of nutraceuticals, and pharmacognosy of marine organisms. The educational system of universities should correspond to these new demands. However, in some areas the educational system is not prepared to face the challenges of the time. The basic requirement is to adopt a complex attitude to biogenic material and utilize the connections of this complexity in the teaching of modern pharmacy.

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Application of Molecular Techniques in Quality Control of Drugs of Natural Origin; A Review

Cited by 2 publications

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Advances in the quality control of fenugreek seeds using chromatographic, spectroscopic and DNA‐based techniques: A comprehensive review

Advances in the quality control of fenugreek seeds using chromatographic, spectroscopic and DNA‐based techniques: A comprehensive review

Pharmacognosy and Its Role in the System of Profile Disciplines in Pharmacy

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